前列腺等组织中一氧化氮水平与雄激素关系的实验研究  

Nitric oxide level in seminal visicle,prostatic and penile tissues of BPH rat models and its relation to androgen

作　　者：颜纯海[1] 薛波新[1] 单玉喜[1] 殷福兴[1] 梁建英[2] 张宏[2] 

机构地区：[1]苏州医学院附属第二医院泌尿外科,215004 [2]苏州医学院附属第二医院血液科,215004

出　　处：《中华泌尿外科杂志》2000年第5期294-295,共2页Chinese Journal of Urology

摘　　要：目的　探讨前列腺等组织中一氧化氮 (NO)水平及其与雄激素的关系。　方法　以丙酸睾丸酮 (TP )皮下注射建立大鼠BPH模型 ,用分光光度法测定各剂量组前列腺、精囊及阴茎组织中NO水平。　结果　各剂量组前列腺及精囊组织中NO水平随雄激素剂量的增加而下降 ,组间差异均有显著性 (P均 <0 .0 5) ;阴茎组织中NO水平则随雄激素剂量的增加而上升 ,组间差异亦均有显著性 (P均 <0 .0 5)。　结论　雄性生殖器官中NO水平受体内雄激素的调控。雄激素对前列腺、精囊组织中的NO水平起负性调节作用 。Objective To investigate the nitric oxide level in seminal vesicle,prostatic and penile tissues and its relation to androgen. Methods BPH rat models were established by subcutaneous injection of testosterone and nitric oxide levels were assessed by spectrophotometry for seminal vesicle,prostatic and penile tissues. Results The nitric oxide level in the seminal vesicle and prostatic tissues decreased with the increase of the testostrone dose (P<0.05).Whereas,the nitric oxide level in the penile tissue elevated with the increase of testosterone dose (P<0.05). Conclusions Antrogen is negatively related to the nitric oxide level in the seminal vesical and prostatic tissues while it is positively related to the nitric oxide level in the penile tissue.

关 键 词：前列腺增生 一氧化氮 雄激素 实验研究 

分 类 号：R697.3[医药卫生—泌尿科学]