NH_2基修饰SiO_2包覆的Fe_3O_4纳米管药物载体的制备及载药研究  

Preparation and drug loading study on amino modified silica encapsulated magnetite nanotubes drug carrier

作　　者：王丹[1] 吕敏婷[1] 谭钊杰[1] 

机构地区：[1]广东药学院药科学院,广东广州510006

出　　处：《广东药学院学报》2012年第2期128-131,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：广东药学院重点培养青年教师基金;广东药学院人才引进科研启动基金项目(2007YKX15)

摘　　要：目的制备NH2基修饰SiO2包覆的Fe3O4纳米管药物载体并研究其载药性能。方法使用水热法制备Fe2O3纳米管,然后用SiO2对其表面进行包覆,再使用H2还原制备SiO2包覆的Fe3O4纳米管,接着用3-氨丙基三乙氧基硅烷对其表面进行—NH2修饰,以水杨酸为模型药物研究所制备载体的载药性能。结果成功制备出NH2基修饰SiO2包覆的Fe3O4纳米管药物载体,载药实验显示:以水为溶剂时,所制备的载体的包封率和载药率分别为54.7%和55.8%;以体积分数50%乙醇为溶剂时,所制备的载体的包封率和载药率分别为22.4%和49.1%。结论成功制备得到形状新颖的载药率高的纳米Fe3O4磁性药物载体。Objective To prepare amino modified and silica encapsulated magnetite nanotubes drug carrier and study its drug loading properties.Methods Firstly,the hematite（Fe2O3） nanotubes were prepared by hydrothermal method,which were coated with SiO2 and reduced in H2 atmosphere.After that,the surface amino modification was carried out with 3-aminopropyltriethoxysilane.At last,the drug-loading properties of the prepared drug carrier were investigated with salicylic acid as a model drug.Results Amino modified and silica encapsulated magnetite nanotubes drug carrier had been prepared successfully.The entrapment efficiency and the drug loading ratio in water were 54.7% and 55.8%,respectively,and in ethanol were 22.4% and 49.1%,respectively.Conclusion Nano Fe3O4 magnetic drug carrier with novel shape and high drug loading ratio has been prepared successfully.

关 键 词：FE3O4 纳米管 药物载体 

分 类 号：TB383.1[一般工业技术—材料科学与工程]