细胞命运抉择的数学模型:活性氧与p53的关系及其意义(英文)  

Mathematical Models of Cell Fate Decision:Implications for ROS and p53

作　　者：孙廷哲[1] 崔隽[1] 沈萍萍[1] 

机构地区：[1]南京大学生命科学学院,医药生物技术国家重点实验室,南京210093

出　　处：《生物物理学报》2012年第5期392-395,共4页Acta Biophysica Sinica

基　　金：supported by grants from the National Natural Science Foundation of China(31070764);the Natural Science Foundation of Jiangsu Province(BK2010049)~~

摘　　要：生物体内的细胞生活在复杂的环境中。在生物体内,活性氧是普遍存在的。生物体内的活性氧可以诱导DNA损伤,最终破坏基因组稳定性。其中,对基因组损伤最严重的是DNA双链断裂损伤。肿瘤抑制因子p53是细胞内介导DNA损伤反应的重要因子。p53可以修复损伤DNA,保护轻度受损细胞。而当细胞受到严重损伤时,p53能够诱发细胞凋亡,从而维持机体稳态。p53的动力学对于细胞的反应性具有重要影响,然而对这方面却缺少系统的认识。因此在本文中,我们主要关注运用数学模型方法研究p53脉冲的动力学性质,从而揭示细胞内潜在的生死选择机制。Cells live in a complex environment where reactive oxygen species are ubiquitously distributed.Reactive oxygen species can lead to genome instability by inducing DNA damage,perhaps the most detrimental forms are DNA double strand breaks.The tumor suppressor p53 is an important factor in mediating DNA damage response and appropriate responsiveness serves to preserve less damaged organisms while initiates apoptotic programs when cells are under severely stressed conditions.How dynamics of p53 shapes the cellular outcomes remains less understood.Here we focus on application of mathematical models for studying how p53 pulses tip the balance between survival and death.

关 键 词：活性氧 p53脉冲 细胞命运 

分 类 号：Q27[生物学—细胞生物学] Q612