端粒-端粒酶系统与氧化还原微环境  

Telomere-Telomerase System and Cellular Redox Microenvironment

作　　者：胡梦瑶[1] 隋宜伦[1] 谢飞舟[2] 施冬云[1] 

机构地区：[1]复旦大学上海医学院生化与分子生物学系,上海200032 [2]复旦大学自由基调控与应用研究中心,上海200032

出　　处：《生物物理学报》2012年第5期411-421,共11页Acta Biophysica Sinica

摘　　要：端粒,作为染色体末端的特殊结构,可以有效保护染色体,防止其降解、末端融合和重组。端粒酶是通过逆转录维持端粒长度的蛋白核酸复合体。二者共同构成了端粒-端粒酶系统。经过近30年的研究,人们发现该系统与人类健康密切相关。氧化应激可导致端粒结构与功能的改变。本文总结了影响端粒、端粒酶结构与功能的不同途径,并分析了氧化还原微环境和氧化应激对其的影响及对人类疾病的作用。Telomere,as a special component of chromosome,can efficiently protect chromosome from degradation,end-to-end fusion and recombination.Telomerase,the enzyme complex is known to re-elongate shortened telomeres and to maintain the loop structure of telomeres.Telomere and telomerase constitute telomere-telomerase system,which was found to be closely related to human health in nearly 30 years＇ research.Evidences have shown that oxidative stress can alter the structure and function of telomere.This paper reviews the different ways to influence the telomere and telomerase,and analyzes the influence of redox microenvironment and oxidative stress on telomere-telomerase and human disease.

关 键 词：端粒 端粒酶 氧化还原微环境 

分 类 号：Q71[生物学—分子生物学]