西米替丁防治新生儿坏死性小肠结肠炎病例分析  

Shmi Butyl Control for Neonatal Necrotizing Intestinal Colitis Case Analysis

作　　者：齐卫斌[1] 沈琼 魏之素[1] 安晓燕[1] 张新荣[1] 

机构地区：[1]石家庄市第四医院新生儿科,石家庄050011 [2]武警河北总队医院儿科,石家庄050081

出　　处：《中国医药导刊》2012年第4期653-654,共2页Chinese Journal of Medicinal Guide

摘　　要：目的：通过探讨早期应用西米替丁防治坏死性小肠结肠炎的效果以明确西米替丁的临床价值。方法：随机分我院早产儿141例（29-34周1000-1500g）为两组,早期（开奶后）给予观察组97例应用西咪替丁5mg/Kg/D PO,用药1-4周后的对照组44例。两组防治效果进行观察。结果：观察组97例无一例坏死性小肠结肠炎的发生均避免和改善了早产儿喂养不耐受的发生。在对照组44例中有4例发生了坏死性小肠结肠炎其中手术治愈1例,内科保守治疗治愈2例,死亡1例。结论：西米替丁早期能够制酸及抑制胃蛋白酶分泌所以保护胃肠粘膜也可以避免胃肠道酸碱度改变,肠道菌群易位。在防治坏死性小肠结肠炎在早产儿中的发病率效果显著,有重要的临床应用价值。Objective：Through the study on the early application of cimetidine preventing necrotizing enterocolitis in order to clear the effect of cimetidine on clinical value.Methods： 141 cases of premature infants were randomly divided into our hospital（29-34 1000~1500g） into two groups,early（open milk） given the observation group of 97 cases using cimetidine 5mg / Kg / D PO,1 ~ 4 weeks after treatment of 44 cases of the control group.Control effect of two groups were observed.Results： The observation group 97 cases with necrotizing enterocolitis are avoided and improvement in premature infants with feeding intolerance occurs.In 44 cases in the control group of 4 cases of necrotizing enterocolitis in which operation cure 1 cases,conservative treatment 2 cases were cured,1 cases died.Conclusion： Cimetidine inhibits early to acid and pepsin secretion so protect the gastrointestinal mucosa can also avoid gastrointestinal pH change,translocation of intestinal flora.In the prevention and treatment of necrotizing enterocolitis in premature infants in the incidence of significant effect,and has important clinical application value.

关 键 词：西咪替丁 坏死性小肠结肠炎 防治 

分 类 号：R722.12[医药卫生—儿科]