硬膜外腔注射碱化溶液对大鼠神经根功能和组织学影响  

Effects on function and histology of nerve root in rats with epidural injection by alkaline solution

作　　者：杨波[1] 杜春晓[1] 李义凯[1] 

机构地区：[1]南方医科大学中医药学院,广州510515

出　　处：《颈腰痛杂志》2012年第3期170-173,共4页The Journal of Cervicodynia and Lumbodynia

基　　金：广东省东莞市医疗卫生单位科研计划项目(编号:200910515025)

摘　　要：目的研究硬膜外腔注射碱化溶液对SD大鼠神经根功能及组织学影响,为硬膜外注射碱化溶液提供实验依据。方法雄性SD大鼠36只,随机分为3组,每组12只。分别为实验组,即碱化溶液组,不加碱化溶液的对照组,以及正常组。实验组与对照组硬膜外腔给药每周1次,连续注射3周。测量实验前及用药后第3周的大鼠对机械刺激缩爪阈值、马尾神经传导速度,并取神经根组织做病理学观察。结果实验前后各组大鼠后肢机械刺激缩爪阈值及马尾神经传导速度比较差异均无统计学意义,各组神经根病理切片也未见明显损害改变。结论碱化溶液骶管注射不会造成神经根功能及组织学的有害影响,可作为安全的配方选择。Objective To study the effects on function and histology of nerve root in SD rats with epidural injection by alkaline solution,providing experimental evidence for epidural injection by alkaline solution.Methods A total of 36 male SD rats were randomly devided into 3 groups,and each group has 12 rats.There were experimental group-just alkaline solution group,control group-just without alkaline solution,and the normal group.Experimental group and control group were weekly treated with epidural injection,for three consecutive weeks.Before experiment and after the third week of being treated,was determined The cauda equina＇ conduction velocity was also measured,and the nerve roots were taken for pathological observation.Results Before and after the experiment,there was no statistically significant differences in the posterior limb＇s retracting threshold for mechanical stimulation of rats among each group,also was the cauda equina＇ conduction velocity in each group.There was no obvious damage change in pathological section of each group＇ nerve root.Conclusion The caudal epidural block with alkaline solution would not cause function and histological harmful influence of nerve roots,which can be used as the formulation of the safe choice.

关 键 词：硬膜外激素注射 碱化溶液 神经根 功能 组织学 

分 类 号：R614.42[医药卫生—麻醉学]