Preparation and Chiral Recognition of New Chiral Stationary Phases Derived from Cellulose Microspheres  

作　　者：JIN Fenfen ZHANG Juan CHEN Wei FAN Qingchun BAI Zhengwu 

机构地区：[1]Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology,Wuhan 430073,Hubei,China

出　　处：《Wuhan University Journal of Natural Sciences》2012年第3期205-210,共6页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Natural Science Foundation of China (50973086);the Research Project of Department of Education of Hubei Province (Z20081501)

摘　　要：A new way to prepare cellulose-type chiral stationary phases （CSPs） has been established in the present work.Cellulose microspheres with a volume-average diameter of 11.5 m were prepared by an emulsion-solidification method.Three new CSPs were obtained by crosslinking the cellulose microspheres with terephthaloyl chloride （TPC）,and then modifying the crosslinked microspheres with 4-methylbenzoyl chloride,3,5-dimethylbenzoyl chloride and 3,5-dichlorobenzoyl chloride,respectively.The microspheres and the CSPs were characterized by FT-IR,element analysis and scanning electronic microscopy （SEM）.The chiral recognition ability of the CSPs was evaluated with high-performance liquid chromatography （HPLC）.The chromatographic results demonstrate that the CSP prepared from 3,5-dichlorobenzoyl chloride possesses better chiral recognition ability compared with two other CSPs.A new way to prepare cellulose-type chiral stationary phases （CSPs） has been established in the present work.Cellulose microspheres with a volume-average diameter of 11.5 m were prepared by an emulsion-solidification method.Three new CSPs were obtained by crosslinking the cellulose microspheres with terephthaloyl chloride （TPC）,and then modifying the crosslinked microspheres with 4-methylbenzoyl chloride,3,5-dimethylbenzoyl chloride and 3,5-dichlorobenzoyl chloride,respectively.The microspheres and the CSPs were characterized by FT-IR,element analysis and scanning electronic microscopy （SEM）.The chiral recognition ability of the CSPs was evaluated with high-performance liquid chromatography （HPLC）.The chromatographic results demonstrate that the CSP prepared from 3,5-dichlorobenzoyl chloride possesses better chiral recognition ability compared with two other CSPs.

关 键 词：cellulose microspheres stationary phase chiral recognition high-performance liquid chromatography 

分 类 号：O636.11[理学—高分子化学]