从352例药品不良反应/事件报告探讨医院药品风险管理重点  

Key Points of Hospital Drug Risk Management in View of 352 Cases of Adverse Drug Reactions/Events

作　　者：陈楠[1] 刘超[2] 

机构地区：[1]南方医科大学附属郑州人民医院药务科,郑州450003 [2]河南省食品药品评价中心,郑州450003

出　　处：《中国医院用药评价与分析》2012年第3期255-258,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:通过分析郑州人民医院药品不良反应/事件(ADR/ADE)发生的规律和特点,探讨医院药品风险管理的重点。方法:对我院352例ADR/ADE报告从发生ADR/ADE的患者的性别、年龄分布、引起ADR/ADE的药品种类、ADR/ADE的类型及主要的临床表现及给药途径等方面进行统计分析。结果:352例ADR/ADE报告中,10岁以下的患者80例,占22.73%;涉及的药品为133种,抗菌药物引起的ADR/ADE最为多见,占59.94%,其次是中药制剂,占13.07%;静脉用药引起的ADR/ADE有330例,占93.75%;主要的ADR/ADE类型为皮肤及其附件损害,占49.17%。结论:ADR/ADE报告和监测是医院进行药品风险管理的重要环节,ADR/ADE报告分析为临床合理用药提供了必要参考,降低了用药风险。OBJECTIVE： To discuss the key points of hospital drug risk management by analyzing the characteristics and regularity of 352 cases of adverse drug reactions/events（ADR/ADE） in Zhengzhou People＇s Hospital.METHODS： A total of 352 ADR/ADE cases collected in our hospital were classified and analyzed statistically in respect of patients＇ age and sex,categories of drugs,main clinical manifestation and routes of administration etc.RESULTS： Of the 352 ADR/ADE cases,80（22.73%） were under 10 years old.The drugs that induced ADR/ADE totaled 133 kinds.The ADR/ ADE were more frequently induced by antibiotics（59.94%） followed by traditional Chinese medicine（13.07%）.330（93.75%） were induced via intravenous administration.The ADR/ADE manifested mainly as lesions of skin and its appendages,accounting for 49.17%.CONCLUSION： The monitoring and reporting of ADR/ADE is an important link in hospital drug risk management.Analysis of ADR/ADE reports provides necessary reference for clinical rational drug use and contributes to reduced medication risk.

关 键 词：药品不良反应/事件 药品风险管理 合理用药 

分 类 号：R969.3[医药卫生—药理学]