影响家兔热原检查结果的因素分析  

Analysis of the influences on rabbits pyrogen test

作　　者：钱秋娟[1] 席亮[1] 赵小洁[1] 魏然[1] 

机构地区：[1]兰州生物制品研究所有限责任公司,兰州730046

出　　处：《微生物学免疫学进展》2012年第2期23-25,共3页Progress In Microbiology and Immunology

摘　　要：目的统计实验数据,分析影响家兔热原检查结果的因素。方法将一定剂量的供试品静脉注入家兔体内,在规定时间内,观察家兔体温升高的情况。结果基础体温≥38.9℃的家兔,其升温≥0.4℃及≥0.6℃的百分比与基础体温<38.9℃家兔相比具有显著性差异(P<0.05),且不同季节家兔升温≥0.4℃的家兔数百分比具有显著性差异(P<0.05),夏秋两季所占百分数高于冬春两季,夏季(6～8月)家兔基础体温较高。结论不同基础体温家兔对热原敏感程度不同,敏感性随家兔基础体温的升高而下降,为保证热原试验结果的准确性,夏季应适当提前热原质检查时间。Objective To analyze the influences on the rabbits pytogen test.Methods Observing the rising temperatures of rabbits injected with blood product during regulated period.Results The percentages of rabbits,which temperature rised ≥0.4 ℃ and≥0.6 ℃ were compared between the basal body temperarure of≥38.9 ℃ and 38.9 ℃,there is significant differences.There is significant differences among seasons,more percentage of rabbits,which temperature rised≥0.4 ℃ in winter and spring than that of rabbits in summer and fall.Between June and august,there is high basal body temperature.Conclusion The rabbits with different basal temperature levels have different sensitivity in pyrogen test.This test should be carried out earlier in summer to ensure the accuracy of tested results.

关 键 词：热原质检查 基础体温 季节 敏感性 

分 类 号：R446.5[医药卫生—诊断学]