磷酸氢钙/氨基酸共聚物生物活性复合材料  

Bioactive composite of dicalcium phosphate and poly(amino acid) copolymer

作　　者：张云飞[1] 魏杰[2] 吕国玉[3] 严永刚[3] 

机构地区：[1]四川大学化学学院,成都610064 [2]华东理工大学教育部医用生物材料工程研究中心,上海200237 [3]四川大学物理科学与技术学院,成都610064

出　　处：《复合材料学报》2012年第3期98-104,共7页Acta Materiae Compositae Sinica

基　　金：国家科技支撑计划(2007BAE13B00)

摘　　要：通过原位聚合法制备了磷酸氢钙/四元氨基酸共聚物(DCP/PAA)复合材料,并采用XRD和IR方法对其组成结构进行了表征,用模拟体液和Tris-HCl溶液分别研究了复合材料的体外生物活性和降解性能。结果表明:DCP/PAA复合材料的无机相与有机相存在着一定的相互作用;聚合反应时间对复合材料的强度有明显的影响,反应时间越长,PAA的黏度越大,材料的抗压强度越高;复合材料具有很好的生物活性,其表面能够在模拟体液中形成磷灰石层,新形成磷灰石的Ca与P原子比为1.59,为缺钙磷灰石;复合材料能够在Tris-HCl溶液中降解,PAA的黏度对复合材料在Tris-HCl中的降解有一定的影响。复合材料浸泡在Tris-HCl溶液中,溶液的pH值在浸泡初期略有下降,但4周后稳定在7.0～7.2,与人体环境pH值接近。A new kind of biocomposite of dicalcium phosphate （DCP）/four element poly （amino acid） copolymer （PAA） was prepared by using polymerization in situ for bone repair, and its composition and structure were characterized by XRD and IR. The in vitro bioactivity and degradability of DCP/PAA composite were determined by using simulated body liquid （SBF） and Tris-HC1 solution, respectively. The results show that the interactions exist between the inorganic and organic phase of the DCP/PAA composite. The polymerized reaction time has significant effects on the mechanical strength of PAA and DCP/PAA composite, and the viscosities of PAA increases with the increase of the reaction time, so the compressive strength is improved. The DCP/PAA composite has good bioactivity because the apatite could be formed on its surfaces after soaking into SBF, and the newly formed apatite is calcium deficient apatite with the Ca/P atom ratio of 1.59. The DCP/PAA composite could be degradable in the Tris-HCI solution, and intrinsic viscosities of PAA have effects on the degradation of the biocomposite. The pH value of the solution decreases slightly after the composite soaking into Tris HC1 solution at initial stages, but it is stable around 7.0-7.2 after 4 weeks later.

关 键 词：磷酸氢钙 氨基酸共聚物 复合材料 生物活性 降解 

分 类 号：TB332[一般工业技术—材料科学与工程]