严重烧伤脏器并发症的内源性细胞损伤机制研究进展  

Advancement in the research of mechanism of endogenous cellular injury in visceral complications as complications af-ter severe burn

作　　者：罗鹏飞[1] 王光毅[1] 夏照帆[1] 

机构地区：[1]第二军医大学长海医院全军烧伤研究所,上海 200433

出　　处：《中华烧伤杂志》2012年第3期183-185,共3页Chinese Journal of Burns

摘　　要：严重烧伤不仅启动了创面修复系统，同时系统地启动了全身应答反应；其不仅涉及局部创面的病理变化，还涉及远隔脏器结构和功能的改变。这种由严重烧伤诱导的、引起远隔器官发生功能损害的机制并非由外界致伤因素直接引发，而是由生物体固有反应（包括激活和抑制2个方面）的过度放大和（或）长时间持续所介导。这种内源性损伤机制是烧伤后病理生理变化的重要组成部分，也是严重烧伤后发生脏器并发症的重要机制。It is of great importance to know the endoge- nous mechanism in burn-induced organ injuries, not only for the understanding of pathophysiological processes after burn, hut al- so for guiding the clinical treatment. Recent studies have wid- ened and deepened our scope and understanding of secondary in- juries to various organs. However, a unaminous understanding of molecular pathway involved in all burn-induced organ injuries has not been attained. Relatively, the mechanism of endogenous cellular injuries as a result of burn injury could be regarded as a common one to explain the causation of cellular injury, and to guide the prevention and treatment for the burn-induced compli- cations using eytoprotection strategy. This review summarized four aspects of the mechanism of endogenous cellular injuries, including cellular injuries induced by ischemic/hypoxic-uxida- rive stress, excessive inflammatory factors released by inflamma- tory cells, immunosuppressinn caused by suppression uf function of adaptive immune cells, and dysfunction of important support- ive cells of various organs.

关 键 词：烧伤 细胞保护 脏器并发症 内源 性损伤 

分 类 号：R644[医药卫生—外科学]