特发性血小板减少性紫癜患者治疗前后Th1/Th2水平变化及其临床意义  

Expression of Th1 and Th2 and its clinical significance in idiopathic thrombocytopenic purpura patients

作　　者：张庆国[1] 朱锋[1] 张鲁勤[1] 朱伟[1] 顾卫军[1] 

机构地区：[1]徐州市第一人民医院血液科,江苏徐州221002

出　　处：《内科理论与实践》2012年第3期218-221,共4页Journal of Internal Medicine Concepts & Practice

基　　金：徐州市科技计划项目(项目编号:XM08C039)

摘　　要：目的:研究特发性血小板减少性紫癜(ITP)患者药物治疗前后辅助性T淋巴细胞(Th)1/Th2细胞因子水平的变化情况及其临床意义。方法:应用流式细胞仪检测60例ITP患者药物治疗前后干扰素γ(IFN-γ)、白细胞介素(IL)-2、IL-4、IL-10水平,分析Th1/Th2细胞因子水平的变化情况,并结合疗效作相关性分析。以60名健康体检者为对照。结果:药物治疗有效的ITP患者治疗后Th1细胞因子IL-2、IFN-γ水平较治疗前及对照组均显著升高(P<0.01)。而Th2细胞因子IL-4及IL-10水平在3组间均无显著性差异(P>0.05),Th1/Th2比例升高。ITP患者Th1细胞因子IL-2、IFN-γ水平在治疗显效组表达均明显高于良效及进步组和无效组(P<0.05),良效及进步组与治疗无效组比较亦有显著性差异(P<0.05);经相关性分析,患者的疗效与IFN-γ、IL-2均呈正相关。结论:ITP患者药物治疗后Th1细胞因子IL-2、IFN-γ表达升高,且Th1与ITP患者疗效密切相关。Objective： To study the change of T helper cell I（Thl）FFh2 and its clinical significance after drug therapy in patients with idiopathic thrombocytopenic purpura （ITP）. Methods： Thl/Th2 cell and levels of cytokines in 60 patients with ITP before and after treatment and 60 healthy donors were determined by flow cytometry. Results： Thl cytokine interleukin（IL）-2 and interferon（IFN）-＇y increased significantly in patients effectively treated than that before treatment and the control group（P〈0.01）, while the Th2 cytokine IL-4 and IL-10 had no significant change （P〉0.05）. The ratio of Thl and Th2 was increased. IL-2 and IFN-γ in highly effective group were higher than that in moderately effective group, and that in moderately effectively group was higher than that in not effective group （P〈0.05）. Correlation analysis showed that efficacy of therapy was positively correlated with the level of IL-2 and IFN-γ. Conclusions： IL-2 and IFN-γ increased significantly after effective treatment, and there was a significant correlation between Thl cells and efficacy of treatment.

关 键 词：特发性血小板减少性紫癜 辅助性T淋巴细胞 干扰素 白细胞介素 

分 类 号：R554.6[医药卫生—血液循环系统疾病]