HCN通道在生物胃肠道起搏机制中作用研究现状  

Research on the Function of HCN Channels in Pace-making Mechanisms of Biological Gastrointestinal Tract

作　　者：徐纯[1] 王景杰[1] 

机构地区：[1]第四军医大学唐都医院消化内科,陕西西安710038

出　　处：《现代生物医学进展》2012年第10期1992-1994,1961,共4页Progress in Modern Biomedicine

摘　　要：HCN通道(hyperpolarization-activated cyclic nucleotide-gated channels)是一种超极化激活的,钠、钾、钙离子混合通透的,直接受cAMP调控的离子通道,在人体内的分布具有一定的组织和细胞特异性,其不仅与神经系统疾病联系紧密,与胃肠道动力障碍疾病也存在一定联系。对HCN通道生理功能、在胃肠起搏电流形成中作用及与疾病的关系的深入了解,必将对今后的研究以及临床治疗有实际意义。Hyperpolarization-activated cyclic nucleotide-gated channels are hyperpolarization-activated ion channels which can be regulated directly by cAMP and penetrated by Na＋,Ka＋ and Ca2＋.The distribution of the HCN channels in human body shows certain specificities in tissues and cells.They are not only in close relevance with nerve system diseases,but also in connection with gastrointestinal motility diseases.A deepgoing understanding of the physiological functions of HCN channels、the role in the formation of pacemaker current and relation with diseases will undoubtedly have practical significance for the researches and clinical treatments in the future.

关 键 词：超极化激活环核苷酸门控阳离子通道 胃肠道 起搏电流 ICC 

分 类 号：Q593[生物学—生物化学] R333[医药卫生—人体生理学]