肝病患者血清补体C3检测的临床意义  

Clinical significance of serum C3 level in patients with liver diseases

作　　者：邱国华[1] 高媛娇[1] 申戈[1] 路遥[1] 张璐[1] 王琳[1] 李明慧[1] 谢尧[1] 

机构地区：[1]首都医科大学附属北京地坛医院,北京100015

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第2期32-35,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的研究血清补体C3水平与不同类型肝病进程之间的关系。方法检测1060例肝病患者的血清补体C3浓度,按其病情分组,并进行组间比较。结果急性肝炎组、慢性肝炎组、肝细胞癌组、肝硬化组和重型肝炎组,其补体C3水平依次降低。急性肝炎组补体C3水平在正常值范围内,重型肝炎组的补体C3水平最低。肝细胞癌组补体C3水平较肝硬化组增高。肝硬化及肝细胞癌合并自发性腹膜炎(SBP)的补体C3水平较未合并SBP组低,差异具有统计学意义(P<0.05)。结论血清补体C3水平与肝病类型密切相关,可以预测疾病的预后,具有重要的临床意义。Objective To investigate whether serum complement C3 concentrations have prognostic relevance for patients with different stages of liver diseases. Methods Total of 1060 cases were reviewed which were divided into different groups according to pathogenetic conditions （acute hepatitis, chronic hepatitis, severe hepatitis, liver cirrhosis and hepatocellular carcinoma）. Serum complement C3 concentrations were analysed and compared among each group, respectively. Results In acute hepatitis, chronic hepatitis, liver cirrhosis, HCC and severe hepatitis groups, the levels of serum complement C3 decreased in order. The level of complement C3 was within nomal range in acute hepatitis group and the lowest in severe hepatitis group, which increased in HCC group compared with liver cirrhosis group. The levels of complement C3 in cirrhosis and HCC groups with spontaneous bacterial peritonitis （SBP） were lower than patients without SBP, and there were significant differences. Conclusions The level of serum complement C3 is an important index to evaluate the liver function of patients with liver diseases and is closely related to the type of liver diseases which could predict the prognosis of the diseases.

关 键 词：补体C3 肝硬化 肝炎 慢性 肝炎 急性 肝炎 重型 癌 肝细胞 

分 类 号：R446.6[医药卫生—诊断学]