69例真菌性败血症的临床分析  

Clinical analysis on 69 patients with candidemia

作　　者：许夕海[1] 余鑫之[1] 熊自忠[1] 王中新[2] 李家斌[1] 

机构地区：[1]安徽医科大学第一附属医院感染病科,合肥市230022 [2]安徽医科大学第一附属医院检验科,合肥市230022

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第2期36-38,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：安徽省卫生厅基金项目资助(2008A001);安徽省自然科学基金项目资助(070413110)

摘　　要：目的探讨真菌败血症的临床特点,以提高临床医生对该病的认识。方法采用回顾性调查分析方法,收集本院1999～2010年血培养真菌阳性败血症病例的临床资料,分析其临床特点、病原菌分布、基础疾病、致病危险因素以及治疗和预后等特点。结果 69例患者的血培养标本中,共分离出71株真菌,最常见的病原菌为非白色念珠菌,共34株,占47.9%;其次为白色念珠菌,共32株,占45.1%;69例患者抗真菌治疗后,好转或治愈28例。结论真菌败血症多发生于具有多种易感因素者。念珠菌属是其主要致病真菌,其中以白色念珠菌为主。对高危患者应重视真菌病原学检查,消除易感因素,及时合理选用抗真菌药物,以上措施有望改善患者预后。Objective To investigate the clinical characteristics, fungal species, predisposing factors and treatment of fungemia. Methods The data of predisposing factors, distribution of fungus, treatment and outcomes of 69 patients with fungemia from 1999 to 2010 were analysed, retrospectively. Results There were 71 strains of fungal species isolated from 69 patients, of which non-Candida albicans were the most frequently isolated （47.9%）, followed by C. albicans （45.1%）. Among the 69 patients,28 patients got better or cured while other patients got worse or discharged without accurate diagnosis or antifungal therapy. Conclusions Fungemia usually occurred in patients with predisposing factors, especially those treated by broad-spectrum antibiotics. Candida albicans are the major pathogens. Isolation of pathogens, antibiotic susceptibility test and correct choice of antifungal agents in high risk patients are critical for the management of patients with candidemia infection.

关 键 词：真菌血症 疾病易感性 抗真菌药 氟康唑 

分 类 号：R519[医药卫生—内科学]