MATHEMATICAL MODELING OF CELL DYNAMICS AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION  

作　　者：RADU PRECUP SMARANDA ARGHIRESCU ANDREICUCUIANU MARGIT SERBAN 

机构地区：[1]Department of Applied Mathematics"Babes Bolyai"University Cluj 400084,Romania [2]Department of Hematology Victor Babes University of Medicine and Pharmacy,Timisoara 300041,Romania [3]Department of Hematology"Iuliu Hatieganu"University of Medicine and Pharmacy,Cluj 400012,Romania [4]Department of Hematology"Victor Babes"University of Medicine and Pharmacy,Timisoara 300041,Romania

出　　处：《International Journal of Biomathematics》2012年第2期139-156,共18页生物数学学报（英文版）

摘　　要：In this paper a basic mathematical model is introduced to describe the dynamics of three ceil lines after allogeneic stem cell transplantation： normal host cells, leukemic host cells and donor cells. Their evolution is one of competitive type and depends upon kinetic and cell-cell interaction parameters. Numerical simulations prove that the evolution can ultimately lead either to the normal hematopoietic state achieved by the expansion of the donor cells and the elimination of the host cells, or to the leukemic hematopoietic state characterized by the proliferation of the cancer line and the suppression of the other cell lines. One state or the other is reached depending on cell-cell interactions （anti-host, anti-leukemia and anti-graft effects） and initial cell concentrations at transplantation.The model also provides a theoretical basis for the control of post-transplant evolution aimed at the achievement of normal hematopoiesis.

关 键 词：Mathematical modeling dynamical system numerical simulation stem celltransplantation acute myeloid leukemia. 

分 类 号：Q25[生物学—细胞生物学] Q2