无痛人工流产术中米索前列醇不同给药途径的效果观察  

Different ways of misoprostol in painless artificial abortion

作　　者：杜景云[1] 杨新颖[1] 梅丽艳[1] 黄菊香[1] 顾群[1] 余木兰[1] 

机构地区：[1]上海市宝山区罗店医院妇产科,上海201908

出　　处：《西部医学》2012年第5期871-873,共3页Medical Journal of West China

摘　　要：目的观察米索前列醇口服及阴道给药在无痛人工流产术中的效果。方法将200例早孕自愿行无痛人工流产术终止妊娠的妇女随机分为4组,每组50例。A组术前3小时口服400μg米索前列醇,B组术前3小时阴道后穹窿放置400μg米索前列醇;C组术前3小时直肠放置400μg米索前列醇;D组术前不用米索前列醇。观察4组宫颈扩张效果,比较术中出血量、手术时间以及副反应。结果 A、B和C组的宫颈扩张效果、术中出血量以及手术时间同D相比具有显著性差异(P<0.05),而A、B和C3组之间无显著性差异(P>0.05);C组恶心、呕吐、腹泻以及术前的阴道出血等不良反应发生率显著高于B、C组(P<0.05)。结论无痛人工流产前口服、阴道后穹窿或直肠放置400μg米索前列醇均可有效扩张宫颈,缩短手术时间,减少术中出血量,直肠给药优于口服与阴道给药。Objective To compare the clinical effects of different ways of misoprostol in painless artificial abortion,and to find the best approach.Methods 200 women with early pregnancy who wanted painless artificial abortion were randomly divided into 4 groups,each 50 cases.Group A received 400μg misoprostol orally 3 hours before operation.Group B were administered 400μg misoprostol to the rectum 3 hours before operation.Group C were administered 400μg misoprostol to the rectum 3 hours before operation.Group D used no misoprostol.The dilatation of cervix,amount of bleeding during operation,the operative time,and side effects wre compared among 3 groups.Results There were significant difference in the degree of cervical dilation,intra-operation blood loss,and the duration of peration in group A 、B and C,comparing with group D（P〈0.05）.There was no significant difference in group A 、B and C（P〈0.05）.The rates of nausea,vomiting and diarrhea in group C was significantly lower than those in group A and B（P〈0.05）.Conclusion Patients administered with 400μg misoprostol orally,intravaginally or to the rectum before painless artificial abortion had the same effect in cervical dilation,reducing amount of bleeding during operation,shortening the operative time.Administering misoprostol to the rectum appears lower gastro-intestinal symptoms,which is fit for patients.

关 键 词：米索前列醇 无痛流产 给药途径 

分 类 号：R719.31[医药卫生—妇产科学]