国产氯卡胺对高危预激综合征的保护作用  

ELECTROPHYSIOLOGIC EFFECTS OF LORCAINIDE ON THE ANTEGRADE CONDUCTION OF ACCESSARY PATHWAY IN WOLFF-PARKINSON WHITE SYNDROME

作　　者：李庚山[1] 高荟瑗 江洪[1] 施冰[1] 陶华璇 蒋锡嘉[1] 陈芳[1] 

机构地区：[1]湖北医学院附属第一医院心脏内科

出　　处：《中国循环杂志》1990年第3期206-207,共2页Chinese Circulation Journal

摘　　要：本文经食管电生理评价静脉注射国产氯卡胺对36例预激综合征(WPW)旁道(AP)前传功能的影响。结果表明:氯卡胺可使25/36例(69.4%)WPW体表ECG预激消失;21/36例(58.3%)在调搏范围内AP失去前传能力。氯卡胺对AP前传的抑制作用不受药前AP前传有效不应期的限制(P<0.1),对≤270ms者亦有良好的抑制作用。The electrophysiologic effects of intravenous administration of a new antiarrhythmic drug, lorcainide, on the antegrade conduction of accessory pathway (AP) were evaluated by t(?)ansesophageal left atrial pacing in 36 patients with-Wolff-Parkinson-White syndrome (WPW). Lorcainide caused complete antegrade conduction block of AP in twenty-one of 36 patients, and there was no difference between 14 patients with AP antegrade effective refractory period (APA-ERP)≤270 ms and 22 patients with APA-ERP>270 ms (P<0.1). Three patients with APA-ERP≤270 ms had atrial fibrillation (2 pationts) and atrial flutter (1 patient) initiated at the control study, and had mainly conduction over the AV nodal-His connection after the drug. It is concluded that the drug could suppress antegrade conduction of AP and may be of potential benefit in patients with atrial fibrillation and atrial flutter in WPW, especially those with a short refractory period.

关 键 词：氯卡胺 WPW 电生理 预激综合征 

分 类 号：R541.770.5[医药卫生—心血管疾病]