氯氰碘柳胺对金黄色葡萄球菌的体外抗菌活性研究  

Study on in vitro antimicrobial activity of closantel to Staphylococcus aureus

作　　者：赵锎[1] 吕火祥[2] 

机构地区：[1]温州医学院附属慈溪医院检验科,浙江慈溪315300 [2]浙江省人民医院检验中心,浙江杭州310014

出　　处：《中华医院感染学杂志》2012年第10期2019-2021,共3页Chinese Journal of Nosocomiology

基　　金：浙江省自然基金资助项目(Y2100445)

摘　　要：目的探讨氯氰碘柳胺对临床分离的金黄色葡萄球菌(SAU)的体外抗菌活性,为进一步探讨其在临床应用的可能性提供依据。方法临床分离的金黄色葡萄球菌102株,其中耐甲氧西林金黄色葡萄球菌(MRSA)46株,甲氧西林敏感金黄色葡萄球菌(MSSA)56株,采用微量肉汤稀释法测定氯氰碘柳胺,对金黄色葡萄球菌的体外最低抑菌浓度(MIC)值。结果氯氰碘柳胺对MRSA或MSSA的MIC值范围均为0.5～2.0 mg/ml,MIC50均为1.0 mg/ml,MIC90均为2.0 mg/ml。结论氯氰碘柳胺对MRSA或MSSA体外均有较好的抗菌活性,两者间的MIC50与MIC90差异均无统计学意义。OBJECTIVE To explore the in vitro antimicrobial activity of closantel to Staphylococcus aureus in vitro,in order to provide basis for further study of its clinical application.METHODS A total of 102 strains of S.aureus were isolated,including 46 strains of methicillin-resistant S.aureus（MRSA） and 56 strains of methicillin-susceptible S.aureus（MSSA）;the in vitro minimal inhibitory concentration（MIC） value of closantel to S.aureus was measured by the micro-broth dilution method.RESULTS The range of the MIC of closantel to MRSA and MSSA were from 0.5 to 2.0 mg/ml,and MIC50 were 1.0 mg/ml,MIC90 were 2.0 mg/ml,respectively.CONCLUSION The closantel has good antibacterial activity to MRSA and MSSA in vitro,the differences in MIC50 and MIC90 of MRSA and MSSA are statistically significant.

关 键 词：金黄色葡萄球菌 甲氧西林耐药 氯氰碘柳胺 体外敏感试验 

分 类 号：R378.11[医药卫生—病原生物学]