梅毒血清固定与神经梅毒的关系  

Relationship between syphilis serofast reaction and neurosyphilis

作　　者：李淑莲 林志锋 张惠姗 林惠玲 童曼莉[2] 刘桂丽[2] 林丽蓉[2] 

机构地区：[1]厦门市湖里区妇幼保健院妇科,福建厦门361009 [2]厦门大学附属中山医院临床检验中心,福建厦门361004

出　　处：《中华医院感染学杂志》2012年第10期2235-2238,共4页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金重大研究计划(91029729);国家自然科学基金(81171625;81101324);福建省社会发展重大研究计划(2011Y4009)

摘　　要：目的探讨梅毒血清固定与神经梅毒的关系。方法回顾性分析2006年6月-2009年5月厦门大学附属中山医院,梅毒血清固定患者的神经梅毒发生情况及其特性。结果 1208例梅毒患者中有梅毒血清固定的411例,梅毒血清固定的发生率为34.02%,其中205例经脑脊液检查,确诊为神经梅毒115例,占56.10%;神经梅毒的临床类型以麻痹性痴呆、脑膜血管梅毒和无症状神经梅毒为主,脑脊液甲苯胺红不加热血清试验、明胶凝集试验、白细胞以及白蛋白异常率均显著高于非神经梅毒。结论梅毒血清固定与神经梅毒密切相关,应进行脑脊液实验室检查,以排除神经梅毒的可能性。OBJECTIVE To study the relationship between syphilis serofast reaction and neurosyphilis.METHODS The characteristics of neurosyphilis in the syphilis serofast reaction patients were retrospectively analyzed.All sera and cerebrospinal fluid（CSF） samples were collected from Zhongshan Hospital,Xiamen University from Jun 2006 to May 2009.RESULTS Among the 1208 patients,411 cases were diagnosed as syphilis serofast reaction.the incidence of serofast reaction was 34.02%,of 205 patients who received cerebrospinal fluid test,115 cases were diagnosed as neurosyphilis,accounting for 56.10%;the general paresis,meningovascular neurosyphilis and asymptomatic neurosyphilis comprised the highest proportion in neurosyphilis.The abnormal rates of CSF-TRUST,CSF-TPPA,CSF-cell counts,and CSF-protein in neurosyphilis group were significantly higher than non-neurosyphilis group.CONCLUSION Syphilis serofast reaction is closely related to neurosyphilis,all syphilis serofast reaction patients should receive the CSF test so as to exclude the possibility of neurosyphilis.

关 键 词：梅毒血清固定 神经梅毒 梅毒非特异性抗体 脑脊液 

分 类 号：R514[医药卫生—内科学]