表面增强拉曼光谱技术在肿瘤病理中的应用  

Applications of Surface-enhanced Raman Spectroscopy in Tumor Pathology

作　　者：陈燕坪[1] 陈刚[1] 郑雄伟[1] 冯尚源[2] 王静[2] 席刚琴[2] 兰风华[3] 陈荣[2] 

机构地区：[1]福建省肿瘤医院病理科,福建福州350014 [2]医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室,福建师范大学,福建福州350007 [3]南京军区福州总医院遗传病分子诊断研究中心,福建福州350001

出　　处：《激光生物学报》2012年第2期103-108,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(11104030;61178090;81101110)

摘　　要：表面增强拉曼散射(Surface-enhanced Raman Scattering,SERS)技术作为鉴定生物分子种类最有力的分析工具之一,具有灵敏度高、特异性强、稳定性好及检测条件温和等优点。目前,SERS技术在肿瘤病理领域的应用尚处于起步阶段,但已显现出良好的应用前景和发展空间。该文简要介绍了SERS的机理、特性及活性基底,并对SERS技术在肿瘤病理的研究进展、局限性及潜在应用价值方面做较为全面的综述。Surface-enhanced Raman scattering （SERS） technology is one of the most powerful analytical techniques for the identification of biological molecular species with high sensitivity, high specificity and good stability, as well as mild conditions of detection. At present, although SERS technique has been applied in tumor pathology in its infancy, SERS has shown good prospects and great potential. A brief introduction of the basic theory and common features of SERS and SERS active substrate, as well as recent advances and limitations of SERS in tumor pathology were presented here.

关 键 词：表面增强拉曼散射(SERS) 肿瘤病理 超敏感检测 

分 类 号：O433.54[机械工程—光学工程] Q631[理学—光学]