遗传性LCAT缺陷症与动脉粥样硬化  

Hereditary LCAT deficiency and athroma

作　　者：王晓黎[1] 曹艳丽[1] 张锦[1] 

机构地区：[1]中国医科大学附属第一临床医院内分泌科,辽宁沈阳110001

出　　处：《中国微生态学杂志》2012年第5期472-475,共4页Chinese Journal of Microecology

基　　金：辽宁省博士启动课题(20111108)

摘　　要：卵磷脂:胆固醇酰基转移酶(lecithin:cholesterol acyltransferase,LCAT)参与胆固醇酯的合成并在高密度脂蛋白(high density lipoprotein,HDL)的代谢中起重要作用。遗传性LCAT缺陷症是一种以低HDL-胆固醇(HDL-C)为特点的罕见遗传疾病。近年来,LCAT在HDL-C代谢中以及在动脉粥样硬化发生和发展中的作用逐渐被本领域研究者所关注。本文就LCAT缺陷症的遗传学和生化学特点做一综述,重点阐述为何尽管HDL-C水平明显减低,LCAT突变携带者却并未发生早期动脉粥样硬化。Lecithin-cholesterol acyltransferase （LCAT） plays an important role in the synthesis of cholesteryl ester and high density lipoprotein （HDL） metabolism. Hereditary LCAT deficiency is a rare genetic disease characterized by very low level of HDL-C. LCAT has gained more and more attention for its role in HDL-C mechanism and in the development of athroma. This article reviewed the genetics and biochemical characters of LCAT deficiency, focusing on why patients with LCAT deficiency don＇t develop athroma even though with a very low HDL-C level.

关 键 词：卵磷脂:胆固醇酰基转移酶 高密度脂蛋白 LCAT缺陷症 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]