中老年男性代谢综合征和前列腺增生关系的研究  

The correlation between metabolic syndrome and benign prostatic hyperplasia in men over 50 years old

作　　者：周哲[1] 王义[1] 蔡建良[1] 晋连超[1] 张祥华[1] 那彦群[1] 

机构地区：[1]北京大学首钢医院北京大学吴阶平泌尿外科医学中心,100144

出　　处：《中华泌尿外科杂志》2012年第5期373-377,共5页Chinese Journal of Urology

摘　　要：目的探讨中老年男性人群中代谢综合征和BPH的关系。方法分层随机选择北京市某社区的中老年男性作为研究对象。调查一般情况，包括年龄、身高、体质量、血压、既往史、IPSS等；抽取空腹静脉血检测血糖、三酰甘油、高密度脂蛋白、PSA；腹部超声测量前列腺体积；测量Qmax。比较代谢综合征组和非代谢综合征组BPH患病率及严重程度；同时比较代谢综合征组内各亚组的差异。结果共调查中老年男性440人。代谢综合征组105人，合并BPH者35人（33．3％）；非代谢综合征组335人，合并BPH者40人（11．9％）。代谢综合征、肥胖和高脂血症组的BPH患病率较高，分别为33．3％、20．4％和25．0％。与非代谢综合征组相比，代谢综合征组中重度LUTS患病率较高（P〈0．05），IPSS、前列腺体积和血清PSA差异有统计学意义（P〈0．05），Qmax差异无统计学意义（P=0．069）。肥胖、高血脂症和糖尿病是BPH的危险因素（OR值分别为1．75、3．36和2．08，P值分别为0．041、0．037和0．045）。结论代谢综合征患者的BPH患病率较高，代谢综合征影响BPH患者的IPSS、前列腺体积和PSA。肥胖、高血脂症、糖尿病是BPH的危险因素；BPH患者诊疗的同时还需考虑是否合并代谢综合征。Objective To evaluate the relationship between metabolic syndrome （MS） and benign prostatic hyperplasia （BPH） in men over 50 years old. Methods Male participants over 50 years old form a community in Beijing were randomly selected. Age, blood pressure, past history, and the international prostate symptom score （IPSS） were recorded. Plasma glucose, triglyceride, high density lipoprotein, prostate specific antigen （PSA） , prostatic volume, and Q were measured. The morbidity and severity of BPH were compared with statistical analysis. Results Four hundred and forty men were enrolled, and were divided into 2 groups ： MS group （ n = 105） and non-MS group （n = 335 ）. Compared to the non-MS, non-obesity, and non-hyperlipidemia group respectively, the morbidity of BPH was higher in MS, obesity and hyper/ipidemia group （33.3% vs. 11.9%, P 〈0.05; 20.4% vs. 11.8%, P〈0.05; 25.0% vs. 14.1% , P =0. 007）. The morbidity of moderate and severe LUTS in MS group was higher than non-MS group （61.9% vs. 31.3%, P 〈 0.05 ）. Significant differences were found in IPSS, prostate volume and PSA between the MS and non-MS groups （ P 〈 0.05） , but not found in Qmax （ P = 0. 069）. Obesity, hyperlipemia and diabetes mellitus were risk factors of BPH （ OR 1.75, 95% CI 1.40 - 21.82, P = 0. 041 ; OR 3.36, 95%CI2.34-48.13, P=0.037; OR2.08, 95%C11.32-13.67, P=0.045）. Conclusions There is higher morbidity of BPH in MS patient. MS could increase IPSS and prostate volume, and reduce PSA in BPH patient. Obesity, hyperlipemia and diabetes mellitus are risk factors of BPH. MS should be considered when treating BPH.

关 键 词：代谢综合征 前列腺增生 回归分析 

分 类 号：R589[医药卫生—内分泌]