百里香挥发油p-环糊精包合工艺研究  

Study on β-Cyclodextrin InclusionTTTechnology of Volatile Oil from Thymmus mongolicus Ronn

作　　者：马君义[1,2] 张继[1,2] 魏相龙[1] 王宝生[1] 汪花丽[1] 

机构地区：[1]西北师范大学生命科学学院,兰州730070 [2]甘肃特色植物有效成分制品工程技术研究中心,兰州730070

出　　处：《中国现代应用药学》2012年第5期422-427,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省科技支撑计划项目(0804GKCA028);西北师范大学大学生学术科研资助金项目(2010-083)

摘　　要：目的研究百里香挥发油p-环糊精(β-CD)包合的最佳工艺条件。方法以挥发油利用率和包合物得率的综合评分为筛选指标,在单因素试验的基础上选择百里香挥发油与p-CD的用量比、包合温度、包合时间为考察因素,采用L9(33)正交试验设计优化百里香挥发油β-CD包合工艺。结果最佳包合工艺条件为百里香挥发油与p-CD的用量比为1:8,包合时间为2.5 h,包合温度为40℃,在此最佳工艺下,包合物得率、挥发油利用率和包合物含油率分别为88.76%,89.62%和9.41%。结论优选得到的百里香挥发油p-CD包合工艺合理、稳定、可行,有效地提高了百里香挥发油的稳定性。OBJECTIVE To study the optimal condition of β-cyelodextrin （β-CD） inclusion technology of volatile oil from Thymus mongolicus Ronn. METHODS With the ratio of volatile oil to β-CD, inclusion temperature and time as the factors, the utilization rate of volatile oil and the yield of inclusion complex as the comprehensive evaluation indices, the optimum preparation technology conditions on the inclusion compounds were selected by the L9（33） orthogonal design which based on the single factor test. RESULTS The optimal inclusion technology conditions were as follows： the ratio of volatile oil to β-CD was 1：8, the inclusion temperature and time was 40 ℃ for 2.5 h. The yield of inclusion complex, the utilization rate of volatile oil and the oil percentage in inclusion complex were 88.76%, 89.62% and 9.41% respectively under this optimal condition. CONCLUSION The optimal inclusion technology conditions are reasonable, stable and feasible, the stability of volatile oil is increased after being included by β-CD.

关 键 词：百里香 挥发油 p-环糊精 包合工艺 

分 类 号：R283.6[医药卫生—中药学]