米托蒽醌聚乳酸缓释毫微粒冻干针剂在动物体内的靶向性研究  

STUDY ON THE LIVER TARGETING PROPERTY OF THE LIVER TARGETED MITOXANTRONE POLYLACTIC ACID EXTENDED-RELEASE NANOPARTICLES IN VIVO

作　　者：徐超群[1] 张志荣[2] 何勤[2] 廖工铁[2] 

机构地区：[1]四川省中药研究所 [2]华西医科大学药学院,四川成都610041

出　　处：《华西药学杂志》2000年第3期164-166,169,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :比较肝靶向米托蒽醌聚乳酸缓释毫微粒 (DHAQ PLA NP)冻干针剂和DHAQ水针剂在小鼠体内的分布规律 ,验证前者的肝靶向性。方法 :采用HPLC法测定静注DHAQ PLA NP和DHAQ水针剂后小鼠血液、心、肝、脾、肺、肾的药物浓度 ,由此计算各器官的相对百分含量。结果 :DHAQ PLA NP冻干针剂在肝脏的分布明显高于DHAQ水针剂 ,在其它器官中的含量则低于水针剂 ,给药 2 4小时后药物在肝中的分布百分率保持在 80 %以上 ,水针剂为 30～ 40 %。结论 :DHAQ PLAOBJECTIVE:To compare the distribution rule of the liver targeted mitoxantrone polylactic acid extendedrelease nanoparticles(DHAQPLANP) and DHAQ solution,prove the liver targeting property of the former in vivo. METHODS:HPLC was used to analyse the drug concentratration of blood,heart,liver,spleen,lung and kidney. The relative content of the organs was calculated. RESULTS: The concentration in the liver of DHAQPLANP is higher and the contents in the heart or kidney are lower than that of DHAQ solution after iv administration. The relative distribution percentage in the liver was more than 80% after 24 hour through iv administration,whereas tranditional DHAQ injection is 30%～40%. CONCLUSION:DHAQPLANP lyophilization injection has good liver targeting property.

关 键 词：米托蒽醌 聚乳酸 缓释毫微粒 肝靶向 抗癌药 

分 类 号：R979.1[医药卫生—药品]