益生注射液抗大鼠腹主动脉移植硬化的实验研究  

EXPERIMENTAL STUDY ON YISHENG HERBAL INJECTION ANTI ABDOMINAL AORTA SCLEROSIS OF TRANSPLANTATION

作　　者：步宏[1] 陈卫国 刘于宾 吴大蓉[3] 程惊秋[2] 王莉[2] 

机构地区：[1]成都军区总医院 [2]华西医科大学附属第一医院,四川成都610041 [3]成都市药物制剂研究所,四川成都610072

出　　处：《华西药学杂志》2000年第3期185-188,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :探讨不同浓度益生注射液A、B两种组分及联合用药对移植物慢性失功 (CAD)的防治效果及作用环节。方法 :利用组织形态观察 ;计算机图象分析 ;过氧化脂质测定和免疫组织化学分析大鼠腹主动脉移植硬化加快模型。结果 :术后 6周A +B及骁悉 (MMF)治疗组能显著抑制血管内膜的增厚 ,B( 10mg .kg 1)、B( 1mg .kg 1)、A+B组术后各期过氧化脂质 (LPO)与术前比无明显差异 ,各组TGF β1表达高峰在术后 2周 ,空白对照组各时间点的表达最强 ,A +B及MMF组表达最弱。结论 :A组分通过抑制T、B淋巴细胞及巨噬细胞增殖、浸润 ,间接下调TGF β1的表达 ,B组分对氧自由基引起的损伤有明显保护作用 ,A +B有协同作用 。OEJECTIVE:To investigate the precluding effect and processing step of the Yisheng herbal injection in different concentration and coalition usage against CAD. METHODS: By abdominal aorta transplantational sclerosis model in rats.RESULTS: Thickenning of endovascular could be inhibited significantly in 6 weeks after operation and MMF treatment group.There is no significant difference in LPO of B(10 mg·kg 1 )、B(1 mg·kg 1 )、A+B(5 mg·kg 1 ) between preoperation and after operation. The peak of TGFβ 1 expression was in 2 weeks after operation. Each time point in control has the highest expression, where as A+B and MMF group have the lower expressions. CONCLUSION: The results suggest that a medicine downregulate indirectly TGFβ 1 expression by inhibiting hyperplasia and infiltration of T、B lymphocytes and macrophage. B medicine plays a protection role for injury caused by oxygen free redical. A+B have the coordinated action which is the same as MMF

关 键 词：益生注射液 腹主动脉移植 硬化 实验研究 

分 类 号：R285.5[医药卫生—中药学]