功能化氧化石墨烯的细胞相容性(英文)  

Cell Biocompatibility of Functionalized Graphene Oxide

作　　者：张晓[1,2] 杨蓉[2] 王琛[2] 衡成林[1] 

机构地区：[1]北京理工大学物理学院,教育部簇科学重点实验室,北京100081 [2]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,北京100190

出　　处：《物理化学学报》2012年第6期1520-1524,共5页Acta Physico-Chimica Sinica

基　　金：supported by the National Natural Science Foundation of China(20911130229,21073047);Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences,China(KJCX2.YW.M15)~~

摘　　要：采用改进的Hummers方法制备了纳米尺度的氧化石墨烯.对氧化石墨烯的表面进行羧基化,并连接上聚乙二醇(PEG)使其在细胞培养液中可溶并能稳定保存.采用透射电镜(TEM)、傅里叶变换红外(FTIR)光谱和zeta电位测量等对修饰后的氧化石墨烯的结构和功能进行了表征.体外细胞实验表明PEG修饰的氧化石墨烯在水中具有良好的可溶性,对A549细胞没有明显的毒性,在生物医药领域具有潜在的应用价值.We report on synthesis of nanoscale graphene oxide （NGO） by modified Hummers＇ method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy （TEM）, Fourier transform infrared （FTIR） spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

关 键 词：氧化石墨烯 纳米材料 生物相容性 表面功能化 

分 类 号：TB383.1[一般工业技术—材料科学与工程]