球囊扩张术建立幼兔动脉狭窄模型的可行性研究  

Feasibility Study of Establishing A Young Rabbit Model of Artery Stenosis by Balloon Dilatation

作　　者：郭军[1] 计晓娟[1] 余更生[1] 吴春[1] 潘征夏[1] 白永虹[1] 王宇[2] 杨汝铃[1] 

机构地区：[1]重庆医科大学附属儿童医院心脏中心,儿童发育疾病研究省部共建教育部重点实验室,儿科学重庆市重点实验室,重庆市(儿童发育重大疾病诊治与预防)国际科技合作基地,重庆400014 [2]重庆医科大学药学院,重庆400014

出　　处：《中国医科大学学报》2012年第5期418-421,共4页Journal of China Medical University

基　　金：重庆市自然科学基金项目(CSTC No.2009BB5267);重庆市卫生局科研项目(2011-2-242)

摘　　要：目的建立幼兔髂动脉狭窄模型。方法新西兰大白兔70只,(60±15)d,随机分为手术组、假手术组、正常组。手术组采用球囊扩张损伤髂动脉内皮,观察其术后管腔面积,内、中膜面积变化情况,并计算其术后狭窄率。结果与正常组相比,手术组术后4周狭窄率高达80.24%。术后内膜、中膜面积显著高于正常组(P<0.001)。假手术组与正常组相比差异无统计学意义(P>0.05)。结论球囊损伤可用于建立幼兔髂动脉狭窄模型,为进一步临床研究提供实验基础。Objective To establish the model of iliac artery stenosis in young New Zealand rabbit.Methods Seventy rabbits,aged（60±15） days,were randomly divided into operated group,sham-operated group,and the normal group.The vascular endothelial linings of the rabbits′ iliac artery in the operated group were injured with balloon expansion through the femoral artery.The lumen area,lining area and membrane area were measured after the surgery.The narrow rate was calculated in the meantime.In sham-operated group,the rabbits′ femoral artery were exposed only.Results Compared with the control group,the lining area and membrane area in the operated group were significantly higher（P 〈 0.001）.Compared with the control group,the sham-operated group showed no obvious statistical significance（P 〉 0.05）.Conclusion It is feasible to establish a young rabbit model of iliac artery stenosis with intra-operative balloon expansion.

关 键 词：髂动脉狭窄 动物模型 新西兰大白兔幼兔 球囊扩张 

分 类 号：R725.4[医药卫生—儿科]