脑脊液IL-17和IL-23检测在诊断细菌性脑膜炎中的意义  

Diagnostic Value of IL-17 and IL-23 in Cerebrospinal Fluid in Bacterial Meningitis

作　　者：卜跃华[1] 解芳[1] 

机构地区：[1]中国医科大学高等职业技术学院检验教研室,沈阳110001

出　　处：《中国医科大学学报》2012年第5期474-475,共2页Journal of China Medical University

摘　　要：目的探讨脑脊液IL-17和IL-23检测在细菌性脑膜炎中的诊断价值。方法对64份脑脊液进行白细胞计数和IL-17、IL-23的检测。应用受试者工作特征曲线(ROC)对其诊断价值进行评价,并采用直线回归方法进行相关性分析。结果细菌性脑膜炎组脑脊液IL-17和IL-23水平明显高于病毒性脑膜炎组和对照组(P<0.01),病毒性脑膜炎组IL-17和IL-23水平高于对照组(P<0.01)。脑脊液IL-17与IL-23、IL-17与白细胞计数、IL-23与白细胞计数呈明显正相关,相关系数分别为0.4980、0.5551和0.5810。结论脑脊液IL-17和IL-23的检测可以用于对细菌性脑膜炎的鉴别诊断。Objective To study IL-17 and IL-23 in the differential diagnosis of bacterial and viral meningitis.Methods The levels of IL-17 and IL-23 in cerebrospinal fluid of 64 cases were measured by ELISA method.The optimal cut-offs of IL-17 and IL-23 were identified by using ROC curve.The correlation among IL-17,IL-23 and WBC count were evaluated using linear regression.Results The levels of IL-17 and IL-23 in cerebrospinal fluid were higher in bacterial meningitis than in viral meningitis and the control（P 〈 0.01）,and the levels of IL-17 and IL-23 were higher in viral meningitis than the control（P 〈 0.01）.The correlations of IL-17 and IL-23,IL-17 and WBC count,IL-23 and WBC count were 0.4980,0.5551 and 0.5810,respectively.Conclusion IL-17 and IL-23 in cerebrospinal fluid in the differential diagnosis of bacterial and other meningitis has clinical application value.

关 键 词：IL-17 IL-23 脑膜炎 脑脊液 

分 类 号：R446.14[医药卫生—诊断学]