艾滋病病毒感染者发酵支原体检出率关联性研究的Meta分析  

A Meta-Analysis of Association of Mycoplasma Fermentans and HIV Infection

作　　者：金辉[1] 高倩[1] 吴建茹[1] 王蓓[1] 

机构地区：[1]东南大学公共卫生学院环境医学工程教育部重点实验室,南京210009

出　　处：《循证医学》2012年第2期112-116,共5页The Journal of Evidence-Based Medicine

基　　金：国家自然科学基金(项目编号3087215600)

摘　　要：目的系统分析发酵支原体和艾滋病病毒感染之间的关联性,并初步探讨发酵支原体对艾滋病病毒感染进程的影响。方法利用中英文电子数据库检索发酵支原体同艾滋病病毒/艾滋病关联性研究文献,使用随机效应模型进行评价。利用亚组和敏感性分析研究组间的异质性。结果纳入11篇文献,艾滋病病毒感染者发酵支原体检出率明显高于非艾滋病病毒感染者(比值比为4.47,95%可信区间1.41～14.15),但存在发表偏倚。亚组分析和敏感性分析均未支持上述结果。结论发酵支原体同艾滋病病毒之间的关联性有待研究。Objective To evaluate the association between mycoplasma fermentans and HIV and the effect of mycoplasma on the progression of HIV. Methods We searched electronic database to identify epidemiological studies on the association between mycoplasma fermentans and HIV infection and to evaluate them by random effect model. Subgroup analysis and sensitivity analysis were used to consider the heterogeneity between included studies. Results Eleven studies meeting our criteria were identified and extracted. Results showed the detection rate of mycoplasma fermentans was significantly higher in HIV infected people than one in the control group （odds ratio=4.47, 95% confidence interval 1.41-14.15）, but publication bias was found between them. Furthermore, subgroup analysis and sensitivity analysis did not support the positive result. Conclusion Future research is expected to explore the association between mycoplasma fermentans and HIV.

关 键 词：艾滋病病毒(HIV) 发酵支原体 META分析 流行病学 

分 类 号：R512.91[医药卫生—内科学]