空腹血糖与胰岛β细胞功能及胰岛素敏感性关系的研究  

Relationship of fasting plasma glucose with β-cell function and insulin sensitivity

作　　者：杨慧杰[1] 毕艳[1] 童国玉[1] 孙婧[1] 陈莹莹[1] 杨东辉[1] 朱大龙[1] 

机构地区：[1]南京大学医学院附属鼓楼医院内分泌科,210008

出　　处：《中国糖尿病杂志》2012年第5期321-324,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金面上项目青年基金(30800539);中央高校基本科研业务费专项资金资助

摘　　要：目的评估FPG与胰岛β细胞功能及IS之间的关系。方法采用多阶段分层整群随机抽样方法对江苏省1277例人群进行研究,根据OGTT分为NGT、IFG、IGT、IGR、T2DM组。IS用ISI及1/HOMA-IR评价;β细胞功能用经IS校正的处置指数DI(包括DI0、DI30、DI120)评估。结果同NGT组ISI、DI0、DI30、DI120相比,IGT组分别下降25.2%、17.1%、37.2%、12.5%;IFG组分别下降23.5%、65.4%、37.6%、37.1%;IGR组分别下降42.7%、70.1%、56.5%、38.1%;T2DM组分别下降44.7%、83.4%、76.0%、66.0%。结论在正常糖耐量阶段,随着FPG升高,IS和胰岛素分泌有下降趋势,两者共同促进FPG的升高。Objective To evaluate the change of β-cell function and insulin sensitivity when fasting plasma glucose （FPG） increased. Methods 1277 subjects from Jiangsu province were randomized into NGT, IFG, IGT, IGR and T2DM groups by 75g OGTT. Insulin sensitivity was measured by ISI and 1/HOMA-IR. β-cell function adjusted by insulin sensitivity was assessed by DI at hasal DI0, early-phase DIso and total DI120. Results Compared with the NGT group, the ISI, DI0, DI30, DI120 were decreased by 25.2%, 17.1%, 37.2%, and 12.5% respectively in the IGT group; 23.5%, 65.4%, 37.6%, and 37.1% respectively in the IFG group; 42. 7%, 70. 1%, 56. 5%, and 38. 1% respectively in the IGR group; 44.7%, 83.4%, 76.0%, and 66.0% respectively in the T2DM group. Conclusion Both the impairment of β-cell function and insulin sensitivity start at the low point of FPG within the normoglycemic range and contribute.to the deterioration of FPG.

关 键 词：糖尿病 2型 Β细胞功能 胰岛素敏感性 空腹血糖 

分 类 号：R587.1[医药卫生—内分泌]