大承气汤加味治疗重症急性胰腺炎的荟萃分析  

Systematic Review and Meta-analysis on Modified Dachengqi Decoction in Treatment of Severe Acute Pancreatitis

作　　者：李津金[1] 芮庆林[1] 

机构地区：[1]江苏省中医院急诊科,南京210029

出　　处：《中国实验方剂学杂志》2012年第10期6-10,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:评价大承气汤加味治疗重症急性胰腺炎的疗效。方法:通过计算机检索国内数据库有关大承气汤加味治疗重症急性胰腺炎的临床文献,按纳入排除标准进行文献筛选,评价入选文献的质量并提取相关资料,用RevMan 4.2.2软件对腹痛缓解时间、血淀粉酶恢复正常时间、治疗有效率和住院时间进行Meta分析。结果:共纳入12篇临床研究文献,病例总数621例。Meta分析结果显示:联合治疗组与常规治疗组相比,大承气汤能够显著缩短腹痛持续时间[SMD=-1.75,95%CI(-2.10,-1.41),P<0.000 01]、血淀粉酶恢复正常时间[SMD=-2.00,95%CI(-2.73,-1.27),P<0.000 01]、住院时间[SMD=-1.51,95%CI(-1.99,-1.03),P<0.000 01];显著提高治疗有效率[OR=3.78,95%CI(2.27,6.28),P<0.000 01]。结论:大承气汤加味能够显著改善重症急性胰腺炎的腹痛症状,缩短疾病的病程,提高治疗的疗效。Objective： To assess the efficacy of modified Dachengqi decoction in treatment of severe acute pancreatitis （SAP）, Method： We searched Chinese database on line by computer and chose articles according to the inclusive and exclusive standards. Then we evaluated the quality of the included articles strictly and obtain information. A Meta analysis was performed using RevMan 4.2.2 software to contrast the disappearing time of abdominal pain, recovering time of serum amylase, clinical efficacy and the hospital period. Result： Twelve clinical articles including 621 cases were ＇analyzed. Compared with conventional treatment group, we detected significant differences between two group in disappearing time of abdominal pain [ SMD = - 1.75, 95% CI （ -2.10, -1.41）, P〈0.00001], recovering time of serum amylase [SMD= -2.00, 95%CI （ -2.73, - 1.27）, P 〈 0. 000 01 ] , clinical efficacy [ OR = 3.78, 95% CI （2.27, 6.28） , P 〈 0. 000 01 ] , hospitalperiod [ SMD = - 1.51, 95% CI （ - 1.99, - 1.03）, P 〈 0.000 01 ]. Conclusion ： Modified Dachengqi decoction can significantly shorten the time of abdominal pain and the course of severe acute pancreatitis, and enhance clinical efficacy.

关 键 词：大承气汤 重症急性胰腺炎 META分析 

分 类 号：R287[医药卫生—中药学]