相似度价比法优选复方蛇床子酊醇提工艺  

Optimization of Alcohol Extraction Technology for Compound Shechuangzi Tincture by Similarity Bid Method

作　　者：段晓鹏[1] 石继连[1] 贺福元[1,2] 黄金红[1] 

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]中药药性与药效国家中医药管理局重点实验室,长沙410208

出　　处：《中国实验方剂学杂志》2012年第10期17-20,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81073142;81173558);湖南省教育厅重点项目(09A068)

摘　　要：目的:建立一种评价和优化中药提取工艺的新方法-相似度价比法。方法:以醇浸出物和蛇床子素含量为评价指标,L9(34)正交试验考察乙醇体积分数、加醇量、浸渍时间及渗漉速度对复方蛇床子酊醇提工艺的影响,采用正交方差分析和相似度价比法综合评价和优选复方蛇床子酊醇提工艺。结果:对于醇提蛇床子素,正交试验结果表明,实验室最佳工艺为13倍量70%乙醇浸渍24 h,以3 mL·min-1·kg-1速度渗漉;相似度价比法分析表明,工业化最佳工艺为11倍量70%乙醇浸渍72 h,以1 mL·min-1·kg-1速度渗漉。结论:相似度价比法是一种优选高收率低成本中药提取工艺的新方法,优选的工艺稳定,可行。Objective： To establish a new method to evaluate and optimize extraction technology conditions of traditional Chinese medicine-similarity bid method. Method： With ethanol extract and the content of osthol as indexes, effect of the concentration of ethanol, the amount of ethanol, dipping time and percolation speed on ethanol extraction technology of compound Shechuangzi tincture by L9 （34） orthogonal test, orthogonal variance analysis and similarity bid method were used to comprehensive evaluate and optimize extraction technology of compound Shechuangzi tincture. Result： For ethanol extraction technology for compound Shechuangzi tincture, results of orthogonal test showed that optimum process in laboratory was as follows： dipped 24 h with 13 times the amount of 70% ethanol at percolation speed of 3 mL. min-t, kg-t while results of similarity bid method showed the best industrialization process was： dipped 72 h with 11 times the amount of 70% ethanol at percolation speed of 1 mL.min^-1· kg^-1. Conclusion： Similarity bid method was a new and effective way in selecting and optimizing optimum industrialized extraction technology for traditional Chinese medicine with higher extraction yield and lower cost, optimized technology was stable and feasible.

关 键 词：复方蛇床子酊 中药提取工艺 夹角余弦法 相似度 相似度价比法 

分 类 号：R283.6[医药卫生—中药学]