染料木素水溶性栓剂处方及制备工艺优选  

Optimization of Prescription and Preparation Technology for Genistein Water-solubility Suppository

作　　者：孟庆杰[1] 潘五九[1] 王伟明[1] 

机构地区：[1]黑龙江省中医研究院,哈尔滨150036

出　　处：《中国实验方剂学杂志》2012年第10期63-65,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究染料木素水溶性栓剂处方及其制备工艺。方法:采用正交试验法筛选以聚乙二醇为主体的水溶性栓剂最佳处方,考察不同比例基质对栓剂外观和融变时限的影响。考察成型温度和冷却时间对栓剂性状和融变时限的影响。结果:染料木素栓剂制剂工艺的影响因素大小为硬脂酸聚烃氧(40)酯>甘油>聚乙二醇4000;确定染料木素水溶性栓剂最佳处方组成及比例为聚乙二醇4000-硬脂酸聚烃氧(40)酯-甘油为6∶3∶4;栓剂最佳成型温度70℃,冷却时间0.5 h。结论:该栓剂的处方设计合理,制备工艺简单可行。Objective： To study on prescription screening and preparation technology of genistein water- solubility suppository. Method： Optimum prescription of this water-solubility suppository with polyethylene glycol as main part was screened by orthogonal design test. Influence of different proportions of matrix on appearance and dissolution variable time limit of this suppository was investigated. Influence of molding temperature and cooling time on appearance and dissolution variable time limit of this suppository was investigated. Result： Range of influencing factors for genistein water-solubility suppository was S-40 〉 glycerine 〉 PEG 4000. The best prescription of genistein water-solubility suppository was PEG 4000-S-40-glycerol 6 ： 3 ： 4. Optimal molding temperature was 70 ℃ ,cooling time was 0.5 h. Conclusion： This optimized prescription was rational. Preparation technique was easy and practicable.

关 键 词：染料木素 栓剂 聚乙二醇 制备工艺 

分 类 号：R283.6[医药卫生—中药学]