3-溴-4,5-二羟基苯甲醛的抗氧化活性  

Antioxidant Activity of 3-bromo-4,5-dihydroxybenzaldehyde

作　　者：张凝[1] 闫慧丽[1] 张立新[1] 朱敏[1] 徐宝芹[1] 王宗花[1] 

机构地区：[1]青岛大学化学化工与环境学院,山东青岛266071

出　　处：《中国实验方剂学杂志》2012年第10期91-94,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省自然科学基金项目(ZR2009BM018)

摘　　要：目的:评价实验室合成的溴酚类化合物3-溴-4,5-二羟基苯甲醛的抗氧化活性。方法:分别用清除1,1-二苯基-2-三硝基苯肼(DPPH)自由基、羟基自由基和超氧阴离子自由基法测定。结果:3-溴-4,5-二羟基苯甲醛对DPPH自由基的清除能力要明显强于维生素C(Vit C)和特丁基对苯二酚(TBHQ),半清除率(IC50)=4.49 mg·L-1;对超氧阴离子自由基的清除能力也强于TBHQ,IC50=0.93 g·L-1;而对羟基自由基的清除能力则稍弱于VC和TBHQ,IC50=122.42 mg·L-1。结论:3-溴-4,5-二羟基苯甲醛具有较强的抗氧化活性,可以作为食品工业中一种有潜力的天然抗氧化剂成分。Objective：The antioxidant activity of synthesized 3-bromo-4,5-dihydroxybenzaldehyde was studied.Method： Radical scavenging effects were determined,with 1,1-diphenyl-2-picrylhydrazyl（DPPH） radical,hydroxyl radical and superoxide anion radical respectively.Result： It was found that 3-bromo-4,5-dihydroxybenzaldehyde had obvious scavenging effect on DPPH radical activity with IC50as 4.49 mg·L-1.It was better than positive controls,Vit C and t-butyl hydroquinone（TBHQ）.The scavenging ability on O-2 radical is stronger than TBHQ,with IC50=0.93 g·L-1,while on hydroxyl free radical,weaker than Vc and TBHQ with IC50=122.42 mg·L-1.Conclusion： The antioxidant activity of 3-bromo-4,5-dihydroxybenzaldehyde was obvious and could be developed to a medicine or antioxidant ingredient in food.

关 键 词：3-溴-4 5-二羟基苯甲醛 抗氧化 1 1-二苯基-2-三硝基苯肼(DPPH) 羟基自由基 超氧阴离子自由基 

分 类 号：R284.1[医药卫生—中药学]