生泰王对小鼠应激能力及体内抗氧化酶活性的影响  

Effects of Shengtaiwang Potion on the Activity of Anti-stress and Antioxidase in Mice

作　　者：章培军[1] 刘斌钰[1] 张丽红[1] 李加善[1] 李丽芬[1] 

机构地区：[1]山西大同大学医学院,山西大同037009

出　　处：《中国实验方剂学杂志》2012年第10期221-223,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山西省科技攻关项目(051085)

摘　　要：目的:观察生泰王饮剂对小鼠应激能力和血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响。方法:取小鼠随机分为生泰王饮剂高、低剂量组和对照组,生泰王高、低剂量组分别ig生泰王饮剂5,2.5 g·kg-1·d-1;对照组ig等剂量的生理盐水,连续给药7 d后行常压耐缺氧实验、小鼠游泳耐疲劳实验、耐寒冷;实验分为4组,生泰王高、低剂量组、对照运动组和对照非运动组,连续给药21 d测定血清丙二醛(MDA)含量、超氧化物歧化酶(SOD)活力的影响并比较生泰王饮剂组与对照组差异。结果:对照运动组血清MDA水平显著性升高,SOD活性显著下降,与对照非运动组比较差异有统计学意义(P<0.01)。生泰王饮剂不同剂量组均可显著性提高血清SOD活力,降低MDA水平,与对照运动组相比,有统计学意义(P<0.05,P<0.01);延长小鼠力竭游泳时间,提高耐疲劳能力,生泰王不同剂量组分别比对照组提高45.18%和37.80%;延长小鼠常压耐缺氧时间,提高抗耐缺氧能力;提高小鼠在低温环境下的耐寒冷能力,降低死亡率;与对照组相比,有统计学意义(P<0.05,P<0.01)。结论:生泰王饮剂可以提高小鼠的应激能力,具有良好的体内抗氧化作用,可以延缓衰老。Objective： To observe the effect of Shengtaiwang potion on the activity of anti-stress and superoxide dismutase （SOD） , malondialdehyde （MDA） in blood serum, and then investigate its role in delaying senility and mechanism involved. Method： Mice were randomly divided into control group （ saline）, 5 , 2.5 g· kg^-1 d^-1 groups of Shengtaiwang potion （oral administration）. Then the tests of hypoxia resistance in nomal pressure, fatigue resistance （anti-tire swimming ） and anti-chilling were performed. The content of MDA and activity of SOD in blood serum was also determined in each group, reapectively. Result： Compared with control group, Shengtaiwang potion could significantly increase the activity of SOD and decrease the concent of MDA in serum; and improve the ab＇ility of anti-hypoxia, anti-fatigue and anti-chilling, owing to extending the time of hypoxia resistance and anti-tire swimming in nomal pressure, decreasing the mortality in hypothermia, respectively. Conclusion： Shengtaiwang potion can improve the ability of anti-stress, had well anti-oxidation in vivo, and then delayed senility.

关 键 词：生泰王饮剂 耐缺氧 耐寒冷 耐疲劳 超氧化物歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]