清热祛痛搽剂对尿酸钠致大鼠痛风性关节炎的影响  

The Effect of Heat-cleaning and Pain-relieving Liniment on Gouty Arthritis Rats by Sodium Urate

作　　者：王永[1] 赵越[1] 章嫡妮[1] 郭瑶[1] 卞慧敏[1] 

机构地区：[1]南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室,南京210029

出　　处：《中国实验方剂学杂志》2012年第10期253-256,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究清热祛痛搽剂对尿酸钠诱导大鼠急性痛风性关节炎(GA)模型的治疗作用。方法:取45只大鼠,按体重随机分成5组。模型对照组,造模后按时间点涂等容积赋形剂;阳性药吲哚美辛组(4.5×10-3g·kg-1),于造模前1 h灌胃给药(10 mL·kg-1);清热祛痛搽剂高剂量组(0.91 g·kg-1)、中剂量组(0.46 g·kg-1)、低剂量组(0.23 g·kg-1),于造模后立即涂药(0.1 mL/只),并于致炎后6,12,24,48 h检测大鼠踝关节容积。结果:清热祛痛搽剂高、中、低剂量在致炎后各时间点均能不同程度的抑制尿酸钠所致大鼠踝关节疼痛,减轻肿胀程度,降低步态评分,与模型对照组比较差异有显著性(P<0.05)。结论:清热祛痛搽剂对尿酸钠引起的痛风性关节炎症有较好的治疗作用。Objective： To study the effect of Heat-cleaning and Pain-relieving liniment on actue gouty arthritis rats induced by sodium urate. Method： Forty-five SD rats were randomly divided into 5 groups： model group rats were smeared equal volume of excipient after modeling by time. Indomethaein group （0. 004 5 g · kg-1） rats were administrated drugs one hour before modeling （10 mL · kg-l）. Heat-cleaning and Pain-relieving liniment high dose （0.91 g · kg-1） group, medium dose （0.46 g · kg-1） group and low dose （0.23 g · kg-1） group rats were smeared after modeling at once, and the volume of rats ankle were detected at 6, 12, 24, 48 h after modeling. Result： Different doses of Heat-cleaning and Pain-relieving liniment all could obviously inhibit the pain of ankle, reduce the degree of swelling, and decrease the score of gait. There was a significant difference compared with the model group （P 〈 0.05）. Conclusion： There was a better therapeutic effect of Heat-cleaning and Pain- relieving liniment on gouty arthritis rats by sodium urate.

关 键 词：清热祛痛搽剂 痛风性关节炎 尿酸钠 

分 类 号：R285.5[医药卫生—中药学]