血红细胞力学性能的纳米压痕实验和有限元模拟  

NANOINDENTATION EXPERIMENT AND FINITE ELEMENT SIMULATION FOR BIOMECHANICAL BEHAVIOR OF RED BLOOD CELL

作　　者：李卫卫[1] 杨庆生[1] 刘志远[1] 

机构地区：[1]北京工业大学机电学院工程力学系,北京100124

出　　处：《力学学报》2012年第3期614-621,共8页Chinese Journal of Theoretical and Applied Mechanics

基　　金：国家自然科学基金(10872011;11172012);北京市自然科学基金(3092006)资助项目~~

摘　　要：采用纳米压痕技术和有限元方法研究了血红细胞的生物力学性能.进行了血红细胞的纳米压痕实验,得到了血红细胞的材料参数和变形形貌;在实验基础上,建立了血红细胞的三维有限元模型,模拟了血红细胞的压痕载荷-位移曲线,并考虑了参数效应.数值模拟结果和实验数据符合很好.通过改变压头与材料之间的摩擦系数和压头曲率半径等参数,比较了载荷-位移曲线的变化情况.研究表明摩擦系数对压痕载荷-位移曲线和应力分布影响很小,而压头曲率对载荷-位移曲线的影响明显.This paper studies the biomechanical behaviors of a red blood cell （RBC） by nanoindentation technique and finite element simulation. The Young＇s modulus and load-displacement curve of RBC are measured by nanoindentation. Then a 3D finite element model of RBC is built to simulate the naoindentation process. The load-displacement curves of RBC are obtained by altering friction coefficients between the tip and curvature radius of the tip. It is shown that the FEM results are agreement with the experimental data for nanoindentation of RBC. The deformation of RBC is obviously influenced by the curvature radius of the tip but slightly by the friction coefficient between the tip and the cell.

关 键 词：血红细胞 生物力学 纳米压痕实验 有限元 

分 类 号：TB33[一般工业技术—材料科学与工程]