水相钯催化Suzuki反应  

Palladium-Catalyzed Suzuki Reaction in Aqueous Media

作　　者：刘宁[1] 刘春[1] 金子林[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室,大连116024

出　　处：《有机化学》2012年第5期860-876,共17页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20976024;21076034);大连理工大学离退休人员科研专项基金(No.DUTTX2011103)资助项目~~

摘　　要：钯催化的Suzuki反应是构建Csp2—Csp2键的主要方法之一,已广泛应用于医药、天然产物及先进功能材料等联芳类化合物的合成.近年来,水相Suzuki反应引起了人们的高度关注.对以纯水及水/有机混溶剂为介质的水相Suzuki反应的研究进展作一综述,特别是围绕如何解决水相Suzuki反应活性的问题,以催化体系为主线,重点介绍了水溶性配体/钯、表面活性剂、微波促进的非水溶性配体/钯及无配体钯等催化体系在水相Suzuki反应中的应用.The palladium-catalyzed Suzuki cross-coupling reaction has become one of the most powerful tools for sp2-sp2 carbon-carbon bond formation. This coupling reaction is increasingly being applied in the synthesis of pharmaceuticals, natu- ral products and advanced functional materials. In recent years, tracted attention from many researchers. This paper reviews the developing aqueous systems for the Suzuki reaction has at- recent progress in the Suzuki reaction using neat water and aqueous-organic co-solvent as reaction media. A large number of different strategies for the Suzuki reaction in water have been developed, in which the authors aim at the solutions to the enhancement of the reactivity of the palladium-catalyzed Su- zuki reaction using water-soluble ligands, surfactants, microwave assistance, or ligand-free system.

关 键 词：SUZUKI反应 钯催化剂 水相体系 

分 类 号：O643.32[理学—物理化学]