盾叶秋海棠药材镇痛及抗凝血作用的初步实验研究  

Study on the analgesic and arresting bleeding effects of Begonia cavalereiherb from Guizhou province

作　　者：肖莉 蒋佳雯[2] 杨亮[2] 徐文芬[2] 黄勇其[2] 

机构地区：[1]贵州省黔西南州食品药品检验所,兴义562400 [2]贵阳中医学院,贵阳550002

出　　处：《西北药学杂志》2012年第3期229-231,共3页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:30660224)

摘　　要：目的观察盾叶秋海棠根茎乙醇提取物(ALE)和水提取物(AQE)的镇痛、抗凝血作用及其急性毒性。方法采用小鼠扭体法、热板法及断尾出血时间(BT)、最大耐受量(MTD)测定法。结果不同剂量的ALE能明显减少醋酸致小鼠扭体次数及延长热板致痛的潜伏期;ALE大剂量时能明显延长小鼠BT。ALE和AQE小鼠口服MTD为3.865和7.175g.kg-1(相当于干燥原生药50g.kg-1),12h内,共3次。结论盾叶秋海棠根茎的ALE具有显著的镇痛及抗凝血作用,且盾叶秋海棠根茎的ALE和AQE的急性毒性均较小。Objective To observe the analgesic and anticoagulative effects of alcoholic extract（ALE） and the aqueous extract（AQE） of rhizome of Begonia cavalerei herb from Guizhou province,and to determine the acute toxicity of the extracts.Methods The indexes were tested as follows：writhes of abdominal cavity on mice caused by ip of acetic acid,the incubation of pain induced by heated plate stimulation in mice,bleeding time（BT） by cutting the mouse′s tail and the maximal tolerance dose（MTD）.Results ALE could obviously decrease the numbers of writhe and prolong the incubation of pain of mice.ALE could obviously shorten BT of mice.MTD of AQE for mice was 7.175 g·kg^-1 and that of ALE was 3.865 g·kg^-1 by ig three times in 12 h（be equal to 3×50 g·kg^-1 of dried herbs in 12 h）.Conclusion The pharmacological basis of ALE of rhizome of Begonia cavalerei herb on analgesia and anticoagulation are proved.The acute toxicity of ALE and AQE of rhizome of Begonia cavalerei herb is slight.

关 键 词：盾叶秋海棠药材 镇痛 抗凝血 急性毒性 

分 类 号：R965[医药卫生—药理学]