氨敏Vc胶囊挥发油超声包合工艺的研究  

Study on the hyperacoustic inclusion process of essential oil of Anmin Vc Capsules

作　　者：马桂芝[1] 滕亮[1] 彭一峰 杨文强 

机构地区：[1]新疆医科大学药学院,乌鲁木齐830011 [2]新疆全安药业有限公司,库尔勒841000

出　　处：《西北药学杂志》2012年第3期238-241,共4页Northwest Pharmaceutical Journal

基　　金：新疆维吾尔自治区科学研究与技术开发计划项目(编号:201033125)

摘　　要：目的优选复方氨敏Vc胶囊中挥发油的超声包合工艺。方法以包封率、收率和载药量为评价指标,采用L9(34)正交实验设计优选挥发油的包合工艺。结果优选包合工艺条件为:β-环糊精与挥发油按8∶1(g∶mL)配比,包合时间35min,超声频率59kHz,超声温度为55℃。结论验证实验表明优选出的包合工艺简单、合理、可行。Objective To optimize the hyperacoustic inclusion process of essential oil of Anmin Vc Capsules.Method The envelopment rate and rate of production were selected as index.L^9（3^4） orthogonal design was adopted to optimize the conditions of inclusion technique.Results The optimized preparation process was as follows：oil to β-CD was 1∶8,supersonic time 35 min,hyperacoustic power 59 kHz,and temperature 55 ℃.Conclusion The results of verification test indicate that the selection process is simple and reasonable.

关 键 词：挥发油 超声法 包合物 正交实验 

分 类 号：R94[医药卫生—药剂学]