胰岛素及其类似物治疗糖尿病进展  

Progress of insulin and its analogs in the treatment of diabetes mellitus

作　　者：韩旭亮[1] 石俊峰[1] 龙丽辉[1] 徐丽[1] 陈琳[1] 吴燕[1] 郑艳侠[1] 马永雯 

机构地区：[1]西安医学院附属医院,西安710077 [2]陕西华远医药商业集团有限责任公司,西安710032

出　　处：《西北药学杂志》2012年第3期277-279,共3页Northwest Pharmaceutical Journal

摘　　要：目的了解胰岛素及其类似物在治疗糖尿病中的应用进展。方法汇总文献资料,对胰岛素及其类似物在药代动力学、药理作用、疗效、不良反应等方面的研究进行总结。结果速效胰岛素、长效胰岛素和吸入胰岛素有独特的药代动力学;艾塞那肽和普兰林肽可以降低餐后高血糖,还可以延缓胃排空,减少能量摄入,使体质量降低。结论仍需要努力开发出更好的胰岛素制剂以便于糖尿病患者使用。Objective To understand the progress of insulins and insulin analogues in the treatment of patients with diabetes.Method The publicated articles were reviewed,and the pharmacokinetics,pharmacology,efficacy,and the adverse reactions of insulins and insulin analogues were summarized.Result Rapid-acting insulins,long-acting insulins and inhaled insulins respectively have the special pharmacokinetics.As far as exenatide and pramlintide are concerned,they have the ability to decrease the postprandial glucose excursions,delay the gastric emptying,reduce energy intake,and therefore to lower the body weight.Conclusion Better insulin preparations should be developed to treat patients with diabetes.

关 键 词：速效胰岛素 长效胰岛素 吸入胰岛素 艾塞那肽 普兰林肽 糖尿病 

分 类 号：R977.1[医药卫生—药品]