一种携载抗黑热病药物两性霉素B控释系统的研制  

PREPARATION OF ALGINATE NANOPARTICLES LOADING AMPHOTERICIN B AGAINST LEISHMANIASIS

作　　者：王雅静[1] 李雄伟[2] 曹伟民[2] 刘佳林[2] 

机构地区：[1]华西医科大学寄生虫学教研室,成都610041 [2]中国科学院成都有机化学研究所

出　　处：《实用寄生虫病杂志》2000年第1期6-8,共3页Journal of Practical Parasitic Diseases

摘　　要：采用天然高分子材料 -阴离子聚多糖作为两性霉素 B的载体基质 ,研制高分子材料两性霉素 B控释系统。由离子凝胶作用所产生的阴离子多糖毫微粒 ,其粒径约 3 0～ 1 0 0 nm ,并且对两性霉素 B具有优良的携载性能 ,携载效率超过 90 % ,载药量达 3 5%。体外释放实验表明携载于海藻酸钠粒子上的两性霉素 B可从粒子载体上逐渐释放出来 ,其释放规律几近于零级释放。本实验制得的海藻酸钠粒子两性霉素 B可进一步用于治疗实验犬内脏利什曼病 。To develop controlled release formulation of amphotercin B, an alginate nanoparticles system has been studied The alginate nanoparticles were prepared in a water system by an ionic gelation process The particle size ranged from 30～100 nm according to the transission electronmicrogram On alginate nanoparticle, the loading efficiency and content of amphotericin B reached above 90% and 35% respectively In vitro release experiment showed that the release of amphotericin B loaded on alginate nanoparticle could be potentially controlled The alginate amphotericin B obtained in the experiment would be applied in treatment of canine leishmaniasis

关 键 词：藻酸盐 毫微粒 两性霉素B 黑热病 

分 类 号：R531.6[医药卫生—内科学]