硝苯地平缓释片联合厄贝沙坦辅助治疗2型糖尿病合并高血压的疗效观察  

Efficacy of Nifedipine Sustained Release Tablets combined with Irbesartan on patients with diabetes and hypertension

作　　者：査正科 许发发[1] 

机构地区：[1]成都军区昆明总医院,云南昆明650031

出　　处：《中国医药导报》2012年第15期93-94,共2页China Medical Herald

摘　　要：目的观察硝苯地平缓释片联合厄贝沙坦辅助治疗2型糖尿病合并高血压患者的临床疗效。方法 2型糖尿病合并高血压患者110例,随机分为治疗组和对照组各55例,两组均继续降糖治疗,对照组给予厄贝沙坦150 mg口服,每日1次;观察组在对照组用药的基础上给予硝苯地平缓释片20 mg口服,每日1次;8周为1个疗程,治疗结束后比较疗效。结果观察组总有效率为92.7%,显著高于对照组78.2%,差异有统计学意义(χ2=4.681,P<0.05)。两组治疗过程中血糖均控制在正常范围,治疗后血压均有下降,观察组血压控制优于对照组(P<0.05);治疗后两组的24 h尿微量白蛋白明显下降,两组相比差异有统计学意义(P<0.05)。两组用药过程中不良反应轻微。结论硝苯地平缓释片联合厄贝沙坦辅助治疗2型糖尿病合并高血压疗效显著,血压控制平稳且安全可靠,值得临床推广。Objective To observe the clinical effect on treatment with Nifedipine Sustained Release Tablets combined with Irbesartan for diabetes and hypertension. Methods 110 patients with diabetes and hypertension were randomly divided into test group and control group, with 55 cases in each group. The two groups were given conventional treatment. The control group was given 150 mg of Irbesartan Tablets, once a day. The test group was given 20 mg Nifedipine Sustained Release Tablets on the base of control group, once a day. Both groups were treated for 8 weeks. The clinical efficacy in the two groups was compared. Results The total effective rate of test group was 92.7%, significantly higher than 78.2% of control group （X2 = 4.68!, P 〈 0.05）. After treatment, the blood pressure and 24 hours urinary albumin of test group were more sig- nificant improvement than before and control group （P 〈 0.05）. Adverse reactions of the two groups were slight during treatment. Conclusion The clinical effect on treatment with Nifedipine Sustained Release Tablets combined with Irbesartan for diabetes and hv13ertension is satisfactory and safe. which is worthv of clinical annlication.

关 键 词：硝苯地平 厄贝沙坦 糖尿病 高血压 

分 类 号：R587.2[医药卫生—内分泌] R544.1[医药卫生—内科学]