超声法合成3,4-二甲氧基-4'-羟基查尔酮  

Ultrasound-assisted Synthesis of 3,4-Dimethoxy-4′-hydroxychalcone

作　　者：杨洁[1] 李立忠[1] 申凤善[2] 李香丹[1] 

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074 [2]延边大学理学院,延吉133002

出　　处：《应用化学》2012年第6期724-726,共3页Chinese Journal of Applied Chemistry

基　　金：湖北省自然科学基金资助项目(2008CDB25)

摘　　要：以3,4-二甲氧基-苯甲醛和对羟基苯乙酮为原料,无水乙醇为溶剂,HCl气体为催化剂,在超声作用下,经Claisen-Schmidt缩合反应合成了3,4-二甲氧基-4'-羟基查尔酮。产物结构经IR和1H NMR进行了表征,在2种原料摩尔比1∶1投料比条件下,优化的合成条件为超声输出功率240 W,反应温度30℃,反应时间20 min,产率达到92.1%,比传统方法反应时间短、操作简便、产率高。3,4-Dimethoxy-4＇-hydroxychalcone was synthesized by the Claisen-Schmidt condensation using 3,4-dimethoxybenzaldehyde and 4＇-hydroxyacetophenone as reagents with ultrasonic radiation and dry HCI（g） as catalyst. The structure of the product was confirmed by IR and 1H NMR. The optimized synthesis conditions were to use anhydrous ethanol as the solvent, reaction temperature of 30 ℃, ultrasonic radiation of 240 W, and radiation time of 20 min. A yield of 92. 1% was obtained for the reaction with 1：1 stoiehiometric ratio for the starting materials. Compared with previous method in the literature, the present procedure requires a shorter reaction time, and has easier work-up and higher yield.

关 键 词：二甲氧基羟基查尔酮 超声波 合成 

分 类 号：O625[理学—有机化学]