司帕沙星与克拉霉素随机对照治疗非淋菌性泌尿生殖道炎50例  

A RANDOMIZED CONTROLLED STUDY ON THE EFFICACY OF SPARFLOXACIN IN COMPARISON WITH CLARITHROMYCIN IN TREATMENT OF NON GONOCOCCAL GENITO URETHRITIS

作　　者：胡鹏[1] 邹启园[1] 蒋玉富[1] 程绮馨[1] 

机构地区：[1]重庆医科大学附属第一医院,重庆400016

出　　处：《中国新药杂志》2000年第3期192-194,共3页Chinese Journal of New Drugs

摘　　要：目的 :评价司帕沙星治疗非淋菌性泌尿生殖道炎的有效性。方法 :采用随机对照方法 ,以克拉霉素为对照。共治疗患者 5 0例 ,司帕沙星组 2 6例 ,po ,2 0 0～ 30 0mg ,qd ;克拉霉素组 2 4例 ,po ,2 5 0mg ,q12h。疗程 7～ 14d。结果 :司帕沙星组与克拉霉素组有效率分别为 92 .3%和 91.7% ,痊愈率分别为 84.6 %和 83.3% ,病原菌清除率分别为 92 .3%和 95 .8% ,不良反应发生率分别为 3.85 %和 8.3% ,经统计学处理无显著性差异 (P >0 .0 5 )。结论OBJECTIVE:To study the efficacy of sparfloxacin in treatment of non gonococcal genito urethritis. METHODS:The study was conducted in 50 patients with non gonococcal genito urethritis. They were randomly divided to receive sparfloxacin in a daily oral dose of 200～300 mg ( n =26) or clarithromycin in twice daily dose of 250 mg ( n =24) and both were treated for 7～14 days.RESULTS:The total effective rate, cure rate, and bacterial eradication rate for sparfloxcin were 92.3% , 84.6%, and 92.3% respectively, for clarthromycin were 91.7%, 83.3%, and 95.8% respectively. There is no significant difference between active and control groups ( P >0.05). The incidence of side effect was 3.85% for sparfloxacin and 8.3% for clarithromycin.CONCLUSION:Sparfloxacin is an effective and safe drug for treatment of non gonococcal urethritis.

关 键 词：司帕沙星 克拉霉素 非淋菌性 泌尿生殖道炎 治疗 

分 类 号：R691.305[医药卫生—泌尿科学]