负载轴向取代硅(IV)酞菁配合物的聚合物纳米粒子的合成与表征  

Synthesis and Characterization of Axial Substituted Silicon(Ⅳ) Phthalocyanine and Its Polymeric Nanoparticles

作　　者：黄宝铨[1] 陈庆华[1] 肖荔人[1] 张胜军[1] 黄静[1] 

机构地区：[1]福建师范大学化学与材料学院,福建福州350007

出　　处：《高分子材料科学与工程》2012年第6期12-15,20,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20604007);福建省自然科学基金资助项目(2012J01200;2011J01029);卫生部科学研究基金资助项目(WKJ2008-2-61)

摘　　要：以二氯硅(IV)酞菁(SiPcCl2)为原料,与2-异丙基-6-甲基-4-嘧啶醇(PyO)反应合成轴向取代二-(2-异丙基-6-甲基-4-嘧啶氧基)硅(IV)酞菁配合物SiPc(PyO)2,并采用元素分析、红外光谱(IR)、核磁共振(1H-NMR)和质谱(MS)对其结构进行了表征。以两亲性嵌段共聚物聚赖氨酸-聚乙二醇-聚赖氨酸(PLL-PEG-PLL)为载体,透析法制备负载SiPc(PyO)2的聚合物纳米粒子SiPc(PyO)2/m。SiPc(PyO)2/m呈球形,直径约35 nm。SiPc(PyO)2包裹入聚合物胶束后,SiPc(PyO)2/m的Q带最大吸收峰强度降低,位置蓝移,荧光强度增加,荧光寿命增长。不同孵育时间HUVEC细胞的SiPc(PyO)2和SiPc(PyO)2/m的药代动力学表明,与自由酞菁3相比,SiPc(PyO)2/m摄取率增加,而且提前1 h达到最大浓度。A axial substituted di-（2-isopropy1-6-methyl-4-pyrimidyloxy） silicon（Ⅳ） phthalocyanine（SiPc（PyO）2） was synthesized by reaction of dichloride silicon（Ⅳ） phthalocyanine with 2-isopropy1-6-methyl-4-pyrimidylol.The structure of（SiPc（PyO）2） was characterized by IR,1H-NMR,electrospray ionization-mass spectrometry（ESI-MS）,UV/Vis,fluorescence spectroscopy and elemental analysis.The polyion complex micelle SiPc（PyO）2/m was prepared using amphiphilic triblock copolymer poly（L-lysine）-poly（ethylene glycol）-poly（L-lysine） as carrier by dialyze method.The morphology and photophysical properties of SiPc（PyO）2/m were characterized by AFM,UV/Vis and fluorescent spectroscopy.The time-dependence uptake amount of SiPc（PyO）2 and SiPc（PyO）2/m in human umbilical vein endothelial cells（HUVEC） cells showed that the uptake amount of SiPc（PyO）2/m was significantly increased compared with SiPc（PyO）2.Therefore,SiPc（PyO）2/m would be a potential photosensitizer and may have a high utility for in vivo photodynaime therapy（PDT） of choroidal neovascularization.

关 键 词：酞菁硅 两亲性嵌段共聚物 聚合物纳米粒子 纳米自组装 

分 类 号：TB383[一般工业技术—材料科学与工程]