调节性T细胞亚群在肥胖发病中的作用  

Effects of regulatory T lymphocyte subset in the pathogenesis of obesity

作　　者：赵汝星[1] 孙磊[1] 陈丽[1] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012

出　　处：《国际内分泌代谢杂志》2012年第3期187-189,共3页International Journal of Endocrinology and Metabolism

摘　　要：CD4^＋CD25^＋Foxp3^＋调节性T细胞（Treg细胞）与效应性T细胞数量和（或）功能状态的失衡触发炎性反应。在健康小鼠及人体内脏脂肪组织中Treg细胞丰富存在，而在肥胖小鼠及人体脂肪中Treg细胞的数量及功能状态存在异常。Treg细胞亚群的异常将直接造成脂肪组织的慢性低度炎性反应状态。由于慢性低度炎性反应状态在肥胖及肥胖相关的胰岛素抵抗的发生、发展中扮演重要角色，Treg细胞将成为其未来研究的一个新热点。The imbalance of quantitive and/or functional status between CD4^＋CD25^＋Foxp3^＋ regu- latory T cells （Treg cells） and effector T lymphocytes triggers inflammatory response. Treg cells are highly enriched in the visceral fat of healthy mice and human. But there are quantitive and/or functional abnormali- ties in obese mice and human. These abnormalities directly lead to the chronic low-grade inflammatory status in adipose tissue. Since the chronic low-grade inflammation plays a critical role in the pathogenesis and de- velopment of obesity and related insulin resistance, Treg cells will become new hot spots for further research.

关 键 词：CD4^+CD25^+FOXP3^+调节性T细胞 肥胖 胰岛素抵抗 炎症 

分 类 号：R589.2[医药卫生—内分泌]