肠道菌群与1型糖尿病的关系  

Relationship between intestinal flora and type 1 diabetes mellitus

作　　者：南金延[1] 刘煜[1] 

机构地区：[1]吉林大学第二医院内分泌科,长春130041

出　　处：《国际内分泌代谢杂志》2012年第3期190-193,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30971398,81170746）;吉林大学科学前沿和交叉学科创新项目（200810015）;霍英东基金委员会青年教师基金资助项目（11041）

摘　　要：1型糖尿病发病机制与遗传因素、环境因素及自身免疫因素均有关，是在遗传因素基础上，由环境因素启动，以T淋巴细胞介导的胰岛β细胞进行性损伤为主要特征的自身免疫性疾病。肠道菌群作为环境因素与1型糖尿病发生有直接关系，可通过改变肠壁通透性和宿主免疫系统影响发病。肠道菌群、宿主免疫及1型糖尿病三者之间存在相互联系，研究肠道菌群可为1型糖尿病的预防和治疗提供线索。The pathogenesis of type 1 diabetes are relates to genetic factors, environmental factors and autoimmune factors. Based on genetic factors and triggered by environmental factors, it is an autoimmune disease characterized by T lymphocytes-mediated progressive damage of islet β cells. As one of environmental factors, intestinal flora has a direct relationship with the occurrence of type 1 diabetes, by changing intestinal permeability and host immune system. There exist interactions among intestinal flora, host intestinal immune and type 1 diabetes. Studying on intestinal flora may provide clues for prevention and treatment of type 1 diabetes.

关 键 词：肠道菌群 肠壁通透性 肠道免疫 1型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]