卵巢功能围早衰患者血清IL-2和TNF-α变化的临床研究  

The Clinical Research on the Concentration of serum Tumor necrosis factor alpha(TNF-α) and interleukin-2(IL-2) of the peri-POF Patient

作　　者：陈丽霞[1] 杨柳明[1] 黄晓利[1] 赵燕[1] 梁晓云[1] 林青梅[1] 

机构地区：[1]广东省佛山市南海区妇幼保健院

出　　处：《中国医疗前沿》2012年第7期56-57,共2页China Healthcare Innovation

基　　金：佛山市科技局课题(编号:20111021020098)

摘　　要：目的通过观察卵巢功能围早衰患者血清白介素(IL-2)和肿瘤坏死因子(TNF-α)水平的变化,进一步探讨卵巢早衰的免疫学发病机制。方法采用放射免疫法对39例卵巢围早衰患者及20例健康妇女血浆IL-2和TNF-α的水平进行检测。结果围早衰组IL-2与对照组无显著性差异(P>0.05),围早衰组TNF-α低于对照组,有非常显著性差异(P<0.01),结论和肿瘤坏死因子改变相关的免疫因素可能是卵巢早衰发生发展的重要因素。Objective From studying the Concentration of serum TNF-α and IL-2 of the peri-POF patient to illuminate the mechanism of POF. Methods Serum tumor necrosis factor alpha（TNF-α） and interleukin-2（IL-2） of the peri-POF patient had been checked by radio-immunity method. Results The concentration of serum TNF-α of the patients ＇are significantly lower than that of the normal people（P〈0.01）. But the IL-2 don＇t have that change（P〉0.05）. Conclusion The change of serum TNF-amaybe an important factor relate to POF.

关 键 词：卵巢早衰 细胞因子 白介素 

分 类 号：R711.75[医药卫生—妇产科学]